2-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)-4-(4-methoxybenzyloxy)-5-methylpyrimidine

Base Information

Chemical Name:2-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)-4-(4-methoxybenzyloxy)-5-methylpyrimidine
CAS No.:1352571-39-1
Molecular Formula:C₃₁H₄₆N₂O₄Si₂
Molecular Weight:566.888
Hs Code.:

Synonyms:2-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)-4-(4-methoxybenzyloxy)-5-methylpyrimidine

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Chemical Property of 2-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)-4-(4-methoxybenzyloxy)-5-methylpyrimidine

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Technology Process of 2-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)-4-(4-methoxybenzyloxy)-5-methylpyrimidine

There total 6 articles about 2-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)-4-(4-methoxybenzyloxy)-5-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352571-05-1
2-chloro-4-((4-methoxybenzyl)oxo)-5-methylpyrimidine

: 1366234-66-3
((5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-phenylene)bis(oxy))bis(tert-butyldimethylsilane)

: 1352571-39-1
2-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)-4-(4-methoxybenzyloxy)-5-methylpyrimidine

Guidance literature:: With sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; at 70 ℃; Inert atmosphere;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1352571-39-1
2-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)-4-(4-methoxybenzyloxy)-5-methylpyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / -40 - 20 °C

2: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 16 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere

With 1H-imidazole; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,2-dimethoxyethane; dichloromethane; tert-butyl methyl ether; water; 3: Suzuki Coupling;

Reference yield:

: 108-46-3
recorcinol

: 1352571-39-1
2-(3,5-bis(tert-butyldimethylsilyloxy)phenyl)-4-(4-methoxybenzyloxy)-5-methylpyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / dichloromethane / -40 - 20 °C

2: 4,4'-di-tert-butyl-2,2'-bipyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tert-butyl methyl ether / 16 h / 100 °C / Inert atmosphere; Microwave irradiation; Sealed tube

3: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 70 °C / Inert atmosphere

With 1H-imidazole; sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine; In 1,2-dimethoxyethane; dichloromethane; tert-butyl methyl ether; water; 3: Suzuki Coupling;