N₁-2-(dimethylaminoethyl)-N₁-methyl-N₄-(4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-yl)-5-methoxy-2-nitrobenzene-1,4-diamine

Base Information

• Chemical Name: N₁-2-(dimethylaminoethyl)-N₁-methyl-N₄-(4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-yl)-5-methoxy-2-nitrobenzene-1,4-diamine
• CAS No.: 1421373-22-9
• Molecular Formula: C₂₃H₂₆N₈O₃
• Molecular Weight: 462.511

Synonyms:N₁-2-(dimethylaminoethyl)-N₁-methyl-N₄-(4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-yl)-5-methoxy-2-nitrobenzene-1,4-diamine

Chemical Property of N₁-2-(dimethylaminoethyl)-N₁-methyl-N₄-(4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-yl)-5-methoxy-2-nitrobenzene-1,4-diamine

Chemical Property:

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Technology Process of N₁-2-(dimethylaminoethyl)-N₁-methyl-N₄-(4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-yl)-5-methoxy-2-nitrobenzene-1,4-diamine

There total 5 articles about N₁-2-(dimethylaminoethyl)-N₁-methyl-N₄-(4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-yl)-5-methoxy-2-nitrobenzene-1,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine (1421373-18-3) + N,N',N'-trimethylenediamine (142-25-6) → N1-2-(dimethylaminoethyl)-N1-methyl-N4-(4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-yl)-5-methoxy-2-nitrobenzene-1,4-diamine (1421373-22-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 85 ℃; for 1.5h;

Reference yield:

4-(pyrazole[1,5-a]pyridin-3-yl)-2-chloropyrimidine → N1-2-(dimethylaminoethyl)-N1-methyl-N4-(4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-yl)-5-methoxy-2-nitrobenzene-1,4-diamine (1421373-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 22 h / 125 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 1.5 h / 85 °C

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide;

Reference yield:

4-fluoro-2-methoxy-5-nitro-phenylamine (1075705-01-9) → N1-2-(dimethylaminoethyl)-N1-methyl-N4-(4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-yl)-5-methoxy-2-nitrobenzene-1,4-diamine (1421373-22-9)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 22 h / 125 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 1.5 h / 85 °C

With toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide;

upstream raw materials:

4-fluoro-2-methoxy-5-nitro-phenylamine

N-(2-methoxy-4-fluoro-5-nitrophenyl)-4-(pyrazole[1,5-a]pyridin-3-yl)pyrimidine-2-amine

N,N',N'-trimethylenediamine

4-fluoro-2-methoxyaniline

Downstream raw materials:

C₂₆H₃₀N₈O₂

N¹-(2-dimethylaminoethyl)-5-methoxy-N¹-methyl-N⁴-(4-pyrazolo[1,5-a]pyridin-3-ylpyrimidin-2-yl)benzene-1,2,4-triamine

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