C₂₂H₂₁BrN₂O₆

Base Information

• Chemical Name: C₂₂H₂₁BrN₂O₆
• CAS No.: 1446416-14-3
• Molecular Formula: C₂₂H₂₁BrN₂O₆
• Molecular Weight: 489.323
• Mol file: 1446416-14-3.mol

Synonyms:C₂₂H₂₁BrN₂O₆

Chemical Property of C₂₂H₂₁BrN₂O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₁BrN₂O₆

There total 6 articles about C₂₂H₂₁BrN₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-Bromo-1H-indole-2,3-dione (87-48-9) → C22H21BrN2O6 (1446416-14-3)

Guidance literature:

Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / toluene / 5 h / 130 °C

2: potassium carbonate; tetrabutylammomium bromide; potassium iodide / acetone / 6 h / 56 °C

3: potassium hydroxide / water; ethanol

4: 4-methyl-morpholine / tetrahydrofuran / 0.5 h / -15 °C

5: 4-methyl-morpholine / tetrahydrofuran / 13 h / -15 - 20 °C

With 4-methyl-morpholine; tetrabutylammomium bromide; potassium carbonate; toluene-4-sulfonic acid; potassium iodide; potassium hydroxide; In tetrahydrofuran; ethanol; water; acetone; toluene;

DOI:10.1016/j.bmc.2012.06.024

Reference yield:

4-bromo-aniline (106-40-1) → C22H21BrN2O6 (1446416-14-3)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium sulfate; hydrogenchloride; hydroxylamine hydrochloride / water / 2 h / 85 °C

2: sulfuric acid / 0.5 h / 60 - 90 °C

3: toluene-4-sulfonic acid / toluene / 5 h / 130 °C

4: potassium carbonate; tetrabutylammomium bromide; potassium iodide / acetone / 6 h / 56 °C

5: potassium hydroxide / water; ethanol

6: 4-methyl-morpholine / tetrahydrofuran / 0.5 h / -15 °C

7: 4-methyl-morpholine / tetrahydrofuran / 13 h / -15 - 20 °C

With 4-methyl-morpholine; hydrogenchloride; sulfuric acid; hydroxylamine hydrochloride; tetrabutylammomium bromide; potassium carbonate; toluene-4-sulfonic acid; sodium sulfate; potassium iodide; potassium hydroxide; In tetrahydrofuran; ethanol; water; acetone; toluene;

DOI:10.1016/j.bmc.2012.06.024

Reference yield:

5’-bromo-1‘,2’-dihydrospiro[1,3-dioxolane-2,3’-indole]-2’-one (75822-54-7) → C22H21BrN2O6 (1446416-14-3)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; tetrabutylammomium bromide; potassium iodide / acetone / 6 h / 56 °C

2: potassium hydroxide / water; ethanol

3: 4-methyl-morpholine / tetrahydrofuran / 0.5 h / -15 °C

4: 4-methyl-morpholine / tetrahydrofuran / 13 h / -15 - 20 °C

With 4-methyl-morpholine; tetrabutylammomium bromide; potassium carbonate; potassium iodide; potassium hydroxide; In tetrahydrofuran; ethanol; water; acetone;

DOI:10.1016/j.bmc.2012.06.024

upstream raw materials:

methyl-2-(5′-bromo-2′-oxospiro[[1,3]dioxolane-2,3′-indoline]-1′-yl) acetate

C₁₂H₁₀BrNO₅

4-bromo-aniline

N-(4-bromophenyl)-2-(hydroxyimino) acetamide

Downstream raw materials:

2-(2-(5'-bromo-2'-oxospiro[[1,3]dioxolane-2,3'-indoline]-1'-yl)acetamido)-N-hydroxy-3-phenylpropanamide