[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetaldehyde

Base Information

Chemical Name:[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetaldehyde
CAS No.:885691-45-2
Molecular Formula:C₂₆H₃₇NO₄
Molecular Weight:427.584
Hs Code.:

Synonyms:[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetaldehyde

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Chemical Property of [3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetaldehyde

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Technology Process of [3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetaldehyde

There total 5 articles about [3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 885691-44-1
[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile

: 885691-45-2
[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetaldehyde

Guidance literature:: [3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile; With diisobutylaluminium hydride; In hexane; toluene; at -78 ℃; for 2h;

With silica gel; In diethyl ether; hexane; toluene; at 0 ℃; for 1h;
DOI:10.1021/ol060178b

Reference yield:

: 4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-benzaldehyde

: 885691-45-2
[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: 50 percent / sodium ethoxide / ethanol / 65 °C

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 0 °C

3.1: 75 percent / glacial acetic acid / 2.67 h / 55 - 70 °C

4.1: DIBAL / toluene; hexane / 2 h / -78 °C

4.2: 85 percent / silica gel / toluene; hexane; diethyl ether / 1 h / 0 °C

With sodium ethanolate; diisobutylaluminium hydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; toluene; 1.1: Knoevenagel condensation;
DOI:10.1021/ol060178b

Reference yield:

: 2-(2-hydroxy-ethyl)-3,5,5-trimethyl-cyclohex-2-enone

: 885691-45-2
[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: 50 percent / sodium ethoxide / ethanol / 65 °C

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 0 °C

3.1: 75 percent / glacial acetic acid / 2.67 h / 55 - 70 °C

4.1: DIBAL / toluene; hexane / 2 h / -78 °C

4.2: 85 percent / silica gel / toluene; hexane; diethyl ether / 1 h / 0 °C

With sodium ethanolate; diisobutylaluminium hydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; toluene; 1.1: Knoevenagel condensation;
DOI:10.1021/ol060178b