[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile

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Chemical Name:[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile
CAS No.:885691-44-1
Molecular Formula:C₂₆H₃₆N₂O₃
Molecular Weight:424.583
Hs Code.:

Synonyms:[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile

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Chemical Property of [3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile

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Technology Process of [3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile

There total 4 articles about [3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 885691-43-0
[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-1-hydroxy-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enyl]-acetonitrile

: 885691-44-1
[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile

Guidance literature:: With acetic acid; at 55 - 70 ℃; for 2.66667h;
DOI:10.1021/ol060178b

Reference yield:

: 2-(2-hydroxy-ethyl)-3,5,5-trimethyl-cyclohex-2-enone

: 885691-44-1
[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 50 percent / sodium ethoxide / ethanol / 65 °C

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 0 °C

3.1: 75 percent / glacial acetic acid / 2.67 h / 55 - 70 °C

With sodium ethanolate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; 1.1: Knoevenagel condensation;
DOI:10.1021/ol060178b

Reference yield:

: 4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-benzaldehyde

: 885691-44-1
[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: 50 percent / sodium ethoxide / ethanol / 65 °C

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 0 °C

3.1: 75 percent / glacial acetic acid / 2.67 h / 55 - 70 °C

With sodium ethanolate; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; 1.1: Knoevenagel condensation;
DOI:10.1021/ol060178b