3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone

Base Information

Chemical Name:3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone
CAS No.:885691-42-9
Molecular Formula:C₂₄H₃₅NO₄
Molecular Weight:401.546
Hs Code.:

Synonyms:3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone

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Chemical Property of 3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone

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Technology Process of 3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone

There total 1 articles about 3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-benzaldehyde

: 2-(2-hydroxy-ethyl)-3,5,5-trimethyl-cyclohex-2-enone

: 885691-42-9
3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone

Guidance literature:: With sodium ethanolate; In ethanol; at 65 ℃;
DOI:10.1021/ol060178b

Reference yield:

: 885691-42-9
3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone

: 75-05-8,26809-02-9
acetonitrile

: 885691-43-0
[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-1-hydroxy-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enyl]-acetonitrile

Guidance literature:: acetonitrile; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone; In tetrahydrofuran; hexane; at -78 - 0 ℃;
DOI:10.1021/ol060178b

Reference yield:

: 885691-42-9
3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone

: C₅₈H₄₃F₁₅N₄O₅

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 0 °C

2.1: 75 percent / glacial acetic acid / 2.67 h / 55 - 70 °C

3.1: DIBAL / toluene; hexane / 2 h / -78 °C

3.2: 85 percent / silica gel / toluene; hexane; diethyl ether / 1 h / 0 °C

4.1: 70 percent / ethanol / 0.5 h / 65 °C

5.1: 48 percent / tetrahydrofuran / 8 h / 60 °C

With diisobutylaluminium hydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; toluene;
DOI:10.1021/ol060178b