3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone

Base Information

• Chemical Name: 3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone
• CAS No.: 885691-42-9
• Molecular Formula: C₂₄H₃₅NO₄
• Molecular Weight: 401.546
• Mol file: 885691-42-9.mol

Synonyms:3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone

Chemical Property of 3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone

There total 1 articles about 3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-benzaldehyde + 2-(2-hydroxy-ethyl)-3,5,5-trimethyl-cyclohex-2-enone → 3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone (885691-42-9)

Guidance literature:

With sodium ethanolate; In ethanol; at 65 ℃;

DOI:10.1021/ol060178b

Reference yield:

3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone (885691-42-9) + acetonitrile (75-05-8,26809-02-9) → [3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-1-hydroxy-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enyl]-acetonitrile (885691-43-0)

Guidance literature:

acetonitrile; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.166667h;

3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone; In tetrahydrofuran; hexane; at -78 - 0 ℃;

DOI:10.1021/ol060178b

Reference yield:

3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enone (885691-42-9) → C58H43F15N4O5

Guidance literature:

Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

1.2: tetrahydrofuran; hexane / -78 - 0 °C

2.1: 75 percent / glacial acetic acid / 2.67 h / 55 - 70 °C

3.1: DIBAL / toluene; hexane / 2 h / -78 °C

3.2: 85 percent / silica gel / toluene; hexane; diethyl ether / 1 h / 0 °C

4.1: 70 percent / ethanol / 0.5 h / 65 °C

5.1: 48 percent / tetrahydrofuran / 8 h / 60 °C

With diisobutylaluminium hydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; toluene;

DOI:10.1021/ol060178b

Downstream raw materials:

[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-1-hydroxy-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-enyl]-acetonitrile

[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetaldehyde

[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetonitrile

2-(3-Cyano-4-{(E)-3-[3-((E)-2-{4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-propenyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)-malononitrile