2-(3-Cyano-4-{(E)-3-[3-((E)-2-{4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-propenyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)-malononitrile

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Chemical Name:2-(3-Cyano-4-{(E)-3-[3-((E)-2-{4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-propenyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)-malononitrile
CAS No.:885691-46-3
Molecular Formula:C₄₂H₄₃F₃N₄O₄
Molecular Weight:724.823
Hs Code.:

2-(3-Cyano-4-{(E)-3-[3-((E)-2-{4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-propenyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)-malononitrile

Synonyms:2-(3-Cyano-4-{(E)-3-[3-((E)-2-{4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-propenyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)-malononitrile

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Chemical Property of 2-(3-Cyano-4-{(E)-3-[3-((E)-2-{4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-propenyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)-malononitrile

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Technology Process of 2-(3-Cyano-4-{(E)-3-[3-((E)-2-{4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-propenyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)-malononitrile

There total 6 articles about 2-(3-Cyano-4-{(E)-3-[3-((E)-2-{4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-propenyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)-malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 885691-45-2
[3-((E)-2-{4-[Ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-acetaldehyde

: 436097-14-2
[3-cyano-4-methyl-5-phenyl-5-(trifluoromethyl)-2(5H)-furanylidene]propanedinitrile

: 885691-46-3
2-(3-Cyano-4-{(E)-3-[3-((E)-2-{4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-propenyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)-malononitrile

Guidance literature:: In ethanol; at 65 ℃; for 0.5h;
DOI:10.1021/ol060178b

Reference yield:

: 2-(2-hydroxy-ethyl)-3,5,5-trimethyl-cyclohex-2-enone

: 885691-46-3
2-(3-Cyano-4-{(E)-3-[3-((E)-2-{4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-propenyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)-malononitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 50 percent / sodium ethoxide / ethanol / 65 °C

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 0 °C

3.1: 75 percent / glacial acetic acid / 2.67 h / 55 - 70 °C

4.1: DIBAL / toluene; hexane / 2 h / -78 °C

4.2: 85 percent / silica gel / toluene; hexane; diethyl ether / 1 h / 0 °C

5.1: 70 percent / ethanol / 0.5 h / 65 °C

With sodium ethanolate; diisobutylaluminium hydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; toluene; 1.1: Knoevenagel condensation;
DOI:10.1021/ol060178b

Reference yield:

: 4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-benzaldehyde

: 885691-46-3
2-(3-Cyano-4-{(E)-3-[3-((E)-2-{4-[ethyl-(2-methoxymethoxy-ethyl)-amino]-phenyl}-vinyl)-2-(2-hydroxy-ethyl)-5,5-dimethyl-cyclohex-2-en-(E)-ylidene]-propenyl}-5-phenyl-5-trifluoromethyl-5H-furan-2-ylidene)-malononitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: 50 percent / sodium ethoxide / ethanol / 65 °C

2.1: LDA / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: tetrahydrofuran; hexane / -78 - 0 °C

3.1: 75 percent / glacial acetic acid / 2.67 h / 55 - 70 °C

4.1: DIBAL / toluene; hexane / 2 h / -78 °C

4.2: 85 percent / silica gel / toluene; hexane; diethyl ether / 1 h / 0 °C

5.1: 70 percent / ethanol / 0.5 h / 65 °C

With sodium ethanolate; diisobutylaluminium hydride; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; ethanol; hexane; toluene; 1.1: Knoevenagel condensation;
DOI:10.1021/ol060178b