Chemical Property of Allantoin
Chemical Property:
- Appearance/Colour:White crystalline powder
- Melting Point:230 °C (dec.)(lit.)
- Refractive Index:1.615
- Boiling Point:478oC
- PKA:8.96(at 25℃)
- Flash Point:230-234 °C
- PSA：113.32000
- Density:1.652 g/cm3
- LogP:-0.43100
- Storage Temp.:Refrigerator
- Solubility.:H2O: soluble0.1g/10 mL, clear, colorless
- Water Solubility.:Slightly soluble in water. Freely soluble in alkalis
- XLogP3:-2.2
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:1
- Exact Mass:158.04399007
- Heavy Atom Count:11
- Complexity:225
- Purity/Quality:
-
99%, *data from raw suppliers
Allantoin *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi,
Xn
- Hazard Codes:Xn,Xi
- Statements:
22-36/37/38
- Safety Statements:
22-24/25-36-26
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Biological Agents -> Plant Oils and Extracts
- Canonical SMILES:C1(C(=O)NC(=O)N1)NC(=O)N
- Recent ClinicalTrials:Study of Alwextin? Cream in Treating Epidermolysis Bullosa
- Recent EU Clinical Trials:An Open Label, Multi-center, Extension Study to Evaluate the Long-term Safety of Zorblisa (SD-101-6.0) in Patients with Epidermolysis Bullosa
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Chemical Composition
Allantoin, chemically known as (2,5-dioxo-4-imidazolidinyl)urea, consists of a heterocyclic compound with a five-membered ring containing a urea substituent in the 4th position.
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Biological Properties
Acts as an intermediate product of the purine catabolic pathway in plants, aiding in nitrogen mobilization.
Plays a role in increasing stress tolerance in plants, including drought, salt, cold, heavy metals, and irradiance.
Enhances wound healing process by modulating the inflammatory response, stimulating fibroblast proliferation, and extracellular matrix synthesis.
Facilitates inter-plant interactions and kin recognition in plants, acting as a signaling molecule.
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Applications in Skin Care
Widely used in skin care products due to its ability to promote healing of scar tissue and scars.
Found in over 1300 cosmetic products. Originally discovered in the callus of the Coffea Arabica plant.
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Synthetic Potential
Allantoin's availability and multifunctionality make it attractive for synthetic purposes, especially in the pharmaceutical industry. Its chemical properties include hydrolysis reactions, complexation with organic and inorganic substrates, and interactions with nucleophilic reagents.
Can serve as a basic azaheterocycle to manufacture a wide range of new compounds, including bioactive ones.
