Technology Process of volixibat
There total 16 articles about volixibat which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
5%-palladium/activated carbon;
In
ethanol;
under 2250.23 Torr;
- Guidance literature:
-
In
ethanol;
at 120 ℃;
for 8h;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: aluminum (III) chloride / 16 h / 20 °C / Reflux
2.1: potassium carbonate; tetrabutylammomium bromide / toluene / 24 h / Reflux
2.2: 12 h
2.3: 1.5 h
3.1: boron trifluoride diethyl etherate; triethylsilane / 8 h / 65 °C
4.1: potassium carbonate / acetonitrile; ethanol; water / 5 °C
4.2: 1 h
5.1: sodium hydrogencarbonate; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; sodium hypochlorite; sodium bromide / dichloromethane; water / 2 h
6.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C
7.1: hydrogen / 5%-palladium/activated carbon / dichloromethane; ethanol / 2250.23 Torr
8.1: ethanol / 8 h / 120 °C / Sealed tube
With
triethylsilane; aluminum (III) chloride; sodium hypochlorite; boron trifluoride diethyl etherate; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; potassium tert-butylate; tetrabutylammomium bromide; hydrogen; sodium hydrogencarbonate; potassium carbonate; sodium bromide;
5%-palladium/activated carbon;
In
tetrahydrofuran; ethanol; dichloromethane; water; toluene; acetonitrile;
