2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide

Base Information

• Chemical Name: 2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide
• CAS No.: 133627-46-0
• Molecular Formula: C12H9Cl2N3O
• Molecular Weight: 282.129
• Hs Code.: 2933399090
• European Community (EC) Number: 603-757-0
• DSSTox Substance ID: DTXSID80439718
• Nikkaji Number: J1.359.176H
• Wikidata: Q72517763
• Mol file: 133627-46-0.mol

Synonyms:133627-46-0;2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide;2-Chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide;2-chloro-N-(2-chloro-4-methylpyridin-3-yl)pyridine-3-carboxamide;2-Chloro-N-(2-chloro-4-methyl-pyridin-3-yl)nicotinamide;Picnic;2-Chloro-N-(2-chloro-4-methyl-3-pyridinyl-3-pyridine) carboxamide(carboxamide);2-Chloro-N-(2-chloro-4-methyl-3-pyridyl)-3-pyridine carboxamide;2-CHLORO-N-(2-CHLORO-4-METHYL-3-PYRIDYL)-3-PYRIDINE CARBOXAMIDE;3-Pyridinecarboxamide, 2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-;SCHEMBL1923392;DTXSID80439718;UVCHGYJPZGYMSW-UHFFFAOYSA-N;MFCD09031256;AKOS014828541;AC-18950;AS-17449;C3241;CS-0186620;FT-0645672;F16427;A806653;2-Chloro-N-(2-chloro-4-methyl-3-pyridyl)nicotinamide;N-(2-Chloro-4-methyl-3-pyridyl)-2-chloronicotinamide;2-chloro-N-(2-chloro-4-methyl-pyridin-3-yl) nicotinamide;2-chloro-N-(2-chloro-4-methyl-pyridin-3-yl)-nicotinamide;2-Chloro-N-(2-Chlor-4-Methyl-3-Pyridyl)3-Pyridine Caboxamide;2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridine carboxamide

Chemical Property of 2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide

Chemical Property:

• Appearance/Colour: Pale yellow solid
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 189-191 °C
• Refractive Index: 1.656
• Boiling Point: 369.848 °C at 760 mmHg
• PKA: 10.20±0.70(Predicted)
• Flash Point: 177.478 °C
• PSA: 54.88000
• Density: 1.447 g/cm³
• LogP: 3.41710
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform, Dichloromethane, Methanol
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 281.0122673
• Heavy Atom Count: 18
• Complexity: 303

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC=C1)Cl)NC(=O)C2=C(N=CC=C2)Cl
• Uses: An intermediate in the synthesis of Nivirapine An intermediate in the synthesis of Nivirapine.

Technology Process of 2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide

There total 4 articles about 2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-Chloronicotinoyl chloride (49609-84-9) + 3-Amino-2-chloro-4-methylpyridine (133627-45-9) → 2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide (133627-46-0)

Guidance literature:

In dichloromethane; 1.) -78 deg C, 1 h, 2.) RT, 23 h;

DOI:10.1002/jhet.5570300328

Reference yield:

2-chloronicotinic acid (2942-59-8) → 2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide (133627-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 99 percent / thionyl chloride / 1 h / Heating

2: 87 percent / CH₂Cl₂ / 1.) -78 deg C, 1 h, 2.) RT, 23 h

With thionyl chloride; In dichloromethane;

DOI:10.1002/jhet.5570300328

Reference yield:

2-chloro-3-nitro-4-methylpyridine (23056-39-5) → 2-chloro-N-(2-chloro-4-methyl-3-pyridinyl)-3-pyridinecarboxamide (133627-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / SnCl₂ * 2 H₂O, conc. HCl / diethyl ether / 0.33 h / Ambient temperature

2: 87 percent / CH₂Cl₂ / 1.) -78 deg C, 1 h, 2.) RT, 23 h

With hydrogenchloride; tin(ll) chloride; In diethyl ether; dichloromethane;

DOI:10.1002/jhet.5570300328

upstream raw materials:

2-Chloronicotinoyl chloride

3-Amino-2-chloro-4-methylpyridine

2-chloronicotinic acid

2-chloro-3-nitro-4-methylpyridine

Downstream raw materials:

Nevirapine

C₂₁H₂₁ClN₄O₃

d4-11-cyclopropyl-4-methyl-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6(11H)-one

5,11-dihydro-11-ethyl-4-methyl-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 133627-46-0 2-Chloro-N-(2-chloro-4-methylpyridin-3-yl)nicotinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send