4-hydroxy-2,6-dimethoxy-3-(3-(4-methoxyphenyl)-3-oxopropanoyl)phenyl 4-methoxybenzoate

Base Information

• Chemical Name: 4-hydroxy-2,6-dimethoxy-3-(3-(4-methoxyphenyl)-3-oxopropanoyl)phenyl 4-methoxybenzoate
• CAS No.: 10176-68-8
• Molecular Formula: C₂₆H₂₄O₉
• Molecular Weight: 480.471
• Mol file: 10176-68-8.mol

Synonyms:4-hydroxy-2,6-dimethoxy-3-(3-(4-methoxyphenyl)-3-oxopropanoyl)phenyl 4-methoxybenzoate

Chemical Property of 4-hydroxy-2,6-dimethoxy-3-(3-(4-methoxyphenyl)-3-oxopropanoyl)phenyl 4-methoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-hydroxy-2,6-dimethoxy-3-(3-(4-methoxyphenyl)-3-oxopropanoyl)phenyl 4-methoxybenzoate

There total 6 articles about 4-hydroxy-2,6-dimethoxy-3-(3-(4-methoxyphenyl)-3-oxopropanoyl)phenyl 4-methoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-dihydroxy-2,4-dimethoxyacetophenone (6962-57-8) + 4-methoxy-benzoyl chloride (100-07-2) → 4-hydroxy-2,6-dimethoxy-3-(3-(4-methoxyphenyl)-3-oxopropanoyl)phenyl 4-methoxybenzoate (10176-68-8)

Guidance literature:

3,6-dihydroxy-2,4-dimethoxyacetophenone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - -10 ℃; for 3h;

4-methoxy-benzoyl chloride; In tetrahydrofuran; at -78 - 20 ℃;

Reference yield:

2,6-dimethoxy-p-quinone (530-55-2,26547-64-8) → 4-hydroxy-2,6-dimethoxy-3-(3-(4-methoxyphenyl)-3-oxopropanoyl)phenyl 4-methoxybenzoate (10176-68-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: zinc; hydrogenchloride / 0.08 h

2.1: boron trifluoride diethyl etherate / 3 h / 120 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 - -10 °C

3.2: -78 - 20 °C

With hydrogenchloride; boron trifluoride diethyl etherate; lithium hexamethyldisilazane; zinc; In tetrahydrofuran;

Reference yield:

4-(acetyloxy)-3,5-dimethoxyphenyl acetate (7702-17-2) + 4-methoxy-benzoyl chloride (100-07-2) → 4-hydroxy-2,6-dimethoxy-3-(3-(4-methoxyphenyl)-3-oxopropanoyl)phenyl 4-methoxybenzoate (10176-68-8)

Guidance literature:

4-(acetyloxy)-3,5-dimethoxyphenyl acetate; With boron trifluoride diethyl etherate; In toluene; at 110 ℃; for 18h;

With water; In toluene; Inert atmosphere;

4-methoxy-benzoyl chloride; Further stages;

DOI:10.1021/op4003642

upstream raw materials:

3,6-dihydroxy-2,4-dimethoxyacetophenone

4-methoxy-benzoyl chloride

2-hydroxy-4,6-dimethoxyacetophenone

2,6-dimethoxy-p-quinone

Downstream raw materials:

5,7-dimethoxy-2-(4-methoxyphenyl)-4-oxo-4H-chromen-6-yl 4-methoxybenzoate

6-hydroxy-5,7-dimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one

ladanein

C₁₈H₁₄O₆

Refernces

• 1、 -. "Flavone derivatives and their use". Paragraph 0091-0092. . Retrieved 2013/10/08.