Technology Process of 3,5-bis(3-bromopropyl)-4-methoxybenzaldehyde
There total 7 articles about 3,5-bis(3-bromopropyl)-4-methoxybenzaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Dichloromethyl methyl ether; 2,6-bis(3-bromopropyl)anisole;
With
titanium tetrachloride;
In
dichloromethane;
at -10 - 20 ℃;
for 4h;
With
hydrogenchloride; water;
In
dichloromethane;
for 0.5h;
Cooling with ice;
DOI:10.1016/j.tet.2012.02.014
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium carbonate; sodium iodide / acetone / 48 h / 45 °C / Inert atmosphere
2.1: borane-THF / tetrahydrofuran / 3.5 h / -10 - 20 °C / Inert atmosphere
2.2: 3 h / 20 - 40 °C / Inert atmosphere
3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 24 h / 0 - 20 °C
4.1: titanium tetrachloride / dichloromethane / 4 h / -10 - 20 °C
4.2: 0.5 h / Cooling with ice
With
borane-THF; carbon tetrabromide; titanium tetrachloride; potassium carbonate; triphenylphosphine; sodium iodide;
In
tetrahydrofuran; dichloromethane; acetone;
1.1: Williamson synthesis;
DOI:10.1016/j.tet.2012.02.014
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 200 - 205 °C / Neat (no solvent)
2.1: potassium carbonate; sodium iodide / acetone / 45 °C
3.1: 200 - 205 °C / Neat (no solvent)
4.1: potassium carbonate; sodium iodide / acetone / 48 h / 45 °C / Inert atmosphere
5.1: borane-THF / tetrahydrofuran / 3.5 h / -10 - 20 °C / Inert atmosphere
5.2: 3 h / 20 - 40 °C / Inert atmosphere
6.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 24 h / 0 - 20 °C
7.1: titanium tetrachloride / dichloromethane / 4 h / -10 - 20 °C
7.2: 0.5 h / Cooling with ice
With
borane-THF; carbon tetrabromide; titanium tetrachloride; potassium carbonate; triphenylphosphine; sodium iodide;
In
tetrahydrofuran; dichloromethane; acetone;
1.1: Claisen rearrangement / 2.1: Williamson synthesis / 3.1: Claisen rearrangement / 4.1: Williamson synthesis;
DOI:10.1016/j.tet.2012.02.014
