(+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[(1-trifluoromethyl-1-(2-trimethylsilylethoxy)methoxy)-2,2,2-trifluoro]ethylthiazol-5-yl}methanol

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Chemical Name:(+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[(1-trifluoromethyl-1-(2-trimethylsilylethoxy)methoxy)-2,2,2-trifluoro]ethylthiazol-5-yl}methanol
CAS No.:362719-63-9
Molecular Formula:C₂₃H₂₇F₈NO₅SSi
Molecular Weight:609.61
Hs Code.:
Mol file:362719-63-9.mol

(+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[(1-trifluoromethyl-1-(2-trimethylsilylethoxy)methoxy)-2,2,2-trifluoro]ethylthiazol-5-yl}methanol

Synonyms:(+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[(1-trifluoromethyl-1-(2-trimethylsilylethoxy)methoxy)-2,2,2-trifluoro]ethylthiazol-5-yl}methanol

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Chemical Property of (+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[(1-trifluoromethyl-1-(2-trimethylsilylethoxy)methoxy)-2,2,2-trifluoro]ethylthiazol-5-yl}methanol Edit

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Technology Process of (+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[(1-trifluoromethyl-1-(2-trimethylsilylethoxy)methoxy)-2,2,2-trifluoro]ethylthiazol-5-yl}methanol

There total 2 articles about (+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[(1-trifluoromethyl-1-(2-trimethylsilylethoxy)methoxy)-2,2,2-trifluoro]ethylthiazol-5-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 362718-98-7
3-cyclopropyloxy-4-difluoromethoxybenzaldehyde

: 362718-80-7
2-{1-trifluoromethyl-1-[(2-trimethylsilylethoxy)methoxy]-2,2,2-trifluoroethyl}thiazole

: 362719-63-9
(+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[(1-trifluoromethyl-1-(2-trimethylsilylethoxy)methoxy)-2,2,2-trifluoro]ethylthiazol-5-yl}methanol

Guidance literature:: 2-{1-trifluoromethyl-1-[(2-trimethylsilylethoxy)methoxy]-2,2,2-trifluoroethyl}thiazole; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 1.5h;

3-cyclopropyloxy-4-difluoromethoxybenzaldehyde; In diethyl ether; hexane; at -78 ℃; for 2.5h;
DOI:10.1021/jm0204542

Reference yield:

: 362718-79-4
1,1,1,3,3,3-hexafluoro-2-(1,3-thiazol-2-yl)propan-2-ol

: 362719-63-9
(+/-)-[(3-cyclopropyloxy-4-difluoromethoxy)phenyl]{2-[(1-trifluoromethyl-1-(2-trimethylsilylethoxy)methoxy)-2,2,2-trifluoro]ethylthiazol-5-yl}methanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 100 percent / diisopropylethylamine / CH₂Cl₂ / 48 h / 20 °C

2.1: n-BuLi / diethyl ether; hexane / 1.5 h / -78 °C

2.2: 94 percent / diethyl ether; hexane / 2.5 h / -78 °C

With n-butyllithium; N-ethyl-N,N-diisopropylamine; In diethyl ether; hexane; dichloromethane;
DOI:10.1021/jm0204542