2-(2-biphenyl-4-ylethyl)-N-(tetrahydro-2H-pyran-2-yloxy)tetrahydrothiophene-2-carboxamide 1,1-dioxide

Base Information

Chemical Name:2-(2-biphenyl-4-ylethyl)-N-(tetrahydro-2H-pyran-2-yloxy)tetrahydrothiophene-2-carboxamide 1,1-dioxide
CAS No.:1354546-70-5
Molecular Formula:C₂₄H₂₉NO₅S
Molecular Weight:443.564
Hs Code.:

Synonyms:2-(2-biphenyl-4-ylethyl)-N-(tetrahydro-2H-pyran-2-yloxy)tetrahydrothiophene-2-carboxamide 1,1-dioxide

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Chemical Property of 2-(2-biphenyl-4-ylethyl)-N-(tetrahydro-2H-pyran-2-yloxy)tetrahydrothiophene-2-carboxamide 1,1-dioxide

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Technology Process of 2-(2-biphenyl-4-ylethyl)-N-(tetrahydro-2H-pyran-2-yloxy)tetrahydrothiophene-2-carboxamide 1,1-dioxide

There total 4 articles about 2-(2-biphenyl-4-ylethyl)-N-(tetrahydro-2H-pyran-2-yloxy)tetrahydrothiophene-2-carboxamide 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 6723-30-4
O-2-tetrahydro-2H-pyranhydroxylamine

: 1354546-69-2
2-(2-biphenyl-4-ylethyl)tetrahydrothiophene-2-carboxylic acid 1,1-dioxide

: 1354546-70-5
2-(2-biphenyl-4-ylethyl)-N-(tetrahydro-2H-pyran-2-yloxy)tetrahydrothiophene-2-carboxamide 1,1-dioxide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 10h;
DOI:10.1021/jm2014748

Reference yield:

: 18342-43-3
1,1-dioxo-tetrahydro-1λ⁶-thiophene-2-carboxylic acid ethyl ester

: 1354546-70-5
2-(2-biphenyl-4-ylethyl)-N-(tetrahydro-2H-pyran-2-yloxy)tetrahydrothiophene-2-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / N,N-dimethyl-formamide / 14 h

2: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; caesium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm2014748

Reference yield:

: 1354546-29-4
ethyl 2-(2-biphenyl-4-ylethyl)tetrahydrothiophene-2-carboxylate 1,1-dioxide

: 1354546-70-5
2-(2-biphenyl-4-ylethyl)-N-(tetrahydro-2H-pyran-2-yloxy)tetrahydrothiophene-2-carboxamide 1,1-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; methanol; water / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 10 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm2014748