butyl-(3-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]phenyl}ethyl)dimethylammonium formate

Base Information

Chemical Name:butyl-(3-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]phenyl}ethyl)dimethylammonium formate
CAS No.:1613620-32-8
Molecular Formula:CHO₂*C₃₀H₃₄F₃N₆O₃
Molecular Weight:628.651
Hs Code.:

butyl-(3-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]phenyl}ethyl)dimethylammonium formate

Synonyms:butyl-(3-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]phenyl}ethyl)dimethylammonium formate

Suppliers and Price of butyl-(3-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]phenyl}ethyl)dimethylammonium formate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of butyl-(3-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]phenyl}ethyl)dimethylammonium formate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of butyl-(3-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]phenyl}ethyl)dimethylammonium formate

There total 22 articles about butyl-(3-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]phenyl}ethyl)dimethylammonium formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-18-6
formic acid

: 1613621-79-6
(R)-5-[4-cyano-2-(2-dimethylamino-ethyl)-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

: 74-88-4
methyl iodide

: 1613620-32-8
butyl-(3-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]phenyl}ethyl)dimethylammonium formate

Guidance literature:: (R)-5-[4-cyano-2-(2-dimethylamino-ethyl)-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester; methyl iodide; In acetonitrile; at 50 ℃; for 1.5h;

formic acid; In water; acetonitrile;

Reference yield:

: 64-18-6
formic acid

: 542-69-8
1-iodo-butane

: 1613621-79-6
(R)-5-[4-cyano-2-(2-dimethylamino-ethyl)-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester

: 1613620-32-8
butyl-(3-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]phenyl}ethyl)dimethylammonium formate

Guidance literature:: 1-iodo-butane; (R)-5-[4-cyano-2-(2-dimethylamino-ethyl)-phenyl]-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidine-6-carboxylic acid methyl ester; In acetonitrile; at 50 ℃; for 1.5h;

formic acid;

Reference yield:

: 1736-70-5
3-trifluoromethylphenylthiourea

: 1613620-32-8
butyl-(3-{5-cyano-2-[(R)-6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethylphenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]phenyl}ethyl)dimethylammonium formate

Guidance literature:: Multi-step reaction with 10 steps

1.1: Tris(trimethylsilyl) phosphate / tetrahydrofuran / 17 h / 75 °C / Inert atmosphere

2.1: urea hydrogen peroxide adduct / ethanol / 2 h / 20 °C

2.2: 2 h / 20 °C

3.1: triethylamine / dichloromethane / 16 h / -78 - 20 °C / Inert atmosphere

4.1: ethanol / 1 h / 160 °C / Microwave irradiation

5.1: daicel chiralpak IC colunm (5 μm, 250 mmx10 mm)

6.1: bis-triphenylphosphine-palladium(II) chloride; N-ethyl-N,N-diisopropylamine; copper(II) iodide / 1,4-dioxane / 1.25 h / 130 °C / Microwave irradiation; Inert atmosphere

7.1: silver nitrate; N-Bromosuccinimide / acetone / 2 h / Cooling with ice

8.1: tetrahydrofuran; acetonitrile / 18 h

9.1: sodium tetrahydroborate; methanol / 1 h / 0 °C

10.1: acetonitrile / 1.5 h / 50 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; N-Bromosuccinimide; Tris(trimethylsilyl) phosphate; urea hydrogen peroxide adduct; silver nitrate; copper(II) iodide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetone; acetonitrile;