C₃₄H₃₆F₂N₈O₈

Base Information

Chemical Name:C₃₄H₃₆F₂N₈O₈
CAS No.:1391918-18-5
Molecular Formula:C₃₄H₃₆F₂N₈O₈
Molecular Weight:722.705
Hs Code.:

C<sub>34</sub>H<sub>36</sub>F<sub>2</sub>N<sub>8</sub>O<sub>8</sub>

Synonyms:C₃₄H₃₆F₂N₈O₈

Suppliers and Price of C₃₄H₃₆F₂N₈O₈

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
N1,N2-bis[1-[4-[[[(4-Fluorophenyl)methyl]amino]carbonyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl]-1-methylethyl]ethanediamide
50mg
$ 950.00

Total 4 raw suppliers

Chemical Property of C₃₄H₃₆F₂N₈O₈

Chemical Property:

Density:1.43±0.1 g/cm3(Predicted)

Purity/Quality:

99.90% ^*data from raw suppliers

N1,N2-bis[1-[4-[[[(4-Fluorophenyl)methyl]amino]carbonyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl]-1-methylethyl]ethanediamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses N1,N2-bis[1-[4-[[[(4-Fluorophenyl)methyl]amino]carbonyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-2-pyrimidinyl]-1-methylethyl]ethanediamide, is an impurity of Raltegravir Potassium (R100300), a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.

Technology Process of C₃₄H₃₆F₂N₈O₈

There total 6 articles about C₃₄H₃₆F₂N₈O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 79-37-8
oxalyl dichloride

: C₁₇H₂₀FN₃O₃

: 1391918-18-5
C₃₄H₃₆F₂N₈O₈

Guidance literature:: With 4-methyl-morpholine; In acetonitrile; at 20 ℃;
DOI:10.1021/op300077m

Reference yield:

: 889131-28-6
5-methyl-1,3,4-oxadiazole-2-carboxylic acid chloride

: 1172131-64-4
2,2-dimethyl-propionic acid 2-(1-amino-1-methyl-ethyl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl ester

: 518048-05-0
raltegravir

: 1391918-18-5
C₃₄H₃₆F₂N₈O₈

Guidance literature:: 5-methyl-1,3,4-oxadiazole-2-carboxylic acid chloride; 2,2-dimethyl-propionic acid 2-(1-amino-1-methyl-ethyl)-4-(4-fluorobenzylcarbamoyl)-1-methyl-6-oxo-1,6-dihydropyrimidin-5-yl ester; With 4-methyl-morpholine; In acetonitrile; at 0 - 5 ℃; for 4h;

With acetic acid; potassium hydroxide; Solvent; Overall yield = 92 %;
DOI:10.1021/op300077m

Reference yield:

: 888504-27-6
2-(1-benzyloxycarbonylamino-1-methyl-ethyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid methyl ester

: 518048-05-0
raltegravir

: 1391918-18-5
C₃₄H₃₆F₂N₈O₈

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 60 - 65 °C

2: triethylamine; dmap

3: hydrogen; 10% Pd/C; glycolic Acid / methanol

4: 4-methyl-morpholine / acetonitrile / 4 h / 0 - 5 °C

With 4-methyl-morpholine; dmap; glycolic Acid; 10% Pd/C; hydrogen; triethylamine; In methanol; acetonitrile;
DOI:10.1021/op300077m