(1R,2S)-N-(2,6-difluoropyridin-4-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide

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Chemical Name:(1R,2S)-N-(2,6-difluoropyridin-4-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide
CAS No.:1369763-81-4
Molecular Formula:C₂₂H₂₀F₂N₄O₂
Molecular Weight:410.423
Hs Code.:

Synonyms:(1R,2S)-N-(2,6-difluoropyridin-4-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide

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Chemical Property of (1R,2S)-N-(2,6-difluoropyridin-4-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide

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Technology Process of (1R,2S)-N-(2,6-difluoropyridin-4-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide

There total 2 articles about (1R,2S)-N-(2,6-difluoropyridin-4-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3512-17-2
2,4,6-trifluoropyridine

: 1369768-75-1
(1R,2S)-2-({[(2,4-dimethylpyrimidin-5-yl)oxy]methyl})-2-phenylcyclopropanecarboxamide

: 1369763-81-4
(1R,2S)-N-(2,6-difluoropyridin-4-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide

: 1369763-80-3
(1R,2S)-N-(4,6-difluoropyridin-2-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide

Guidance literature:: (1R,2S)-2-({[(2,4-dimethylpyrimidin-5-yl)oxy]methyl})-2-phenylcyclopropanecarboxamide; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 10 - 35 ℃; for 0.166667h;

2,4,6-trifluoropyridine; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 96h;

Reference yield:

: 1369767-18-9
(1R,2S)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxylic acid

: 1369763-81-4
(1R,2S)-N-(2,6-difluoropyridin-4-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide

: 1369763-80-3
(1R,2S)-N-(4,6-difluoropyridin-2-yl)-2-{[(2,4-dimethylpyrimidin-5-yl)oxy]methyl}-2-phenylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonium chloride / N,N-dimethyl-formamide / 168 h / 10 - 35 °C

2.1: sodium hydride / 1-methyl-pyrrolidin-2-one / 0.17 h / 10 - 35 °C

2.2: 96 h / 100 °C

With sodium hydride; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;