1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-5-chloro-2,4-difluorobenzene

Base Information

Chemical Name:1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-5-chloro-2,4-difluorobenzene
CAS No.:333447-50-0
Molecular Formula:C₂₅H₁₇Cl₃F₂O₅
Molecular Weight:541.763
Hs Code.:

Synonyms:1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-5-chloro-2,4-difluorobenzene

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Chemical Property of 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-5-chloro-2,4-difluorobenzene

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Technology Process of 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-5-chloro-2,4-difluorobenzene

There total 3 articles about 1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-5-chloro-2,4-difluorobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 21740-23-8
3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride

: 333447-43-1
5-chloro-2,4-difluoro-1-iodobenzene

: 333447-51-1
1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-β-D-ribofuranosyl)-5-chloro-2,4-difluorobenzene

: 333447-50-0
1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-5-chloro-2,4-difluorobenzene

Guidance literature:: 3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride; With iodine; magnesium; In tetrahydrofuran; at 40 ℃; for 1h;

With cadmium(II) chloride; for 1h; Heating;

5-chloro-2,4-difluoro-1-iodobenzene; at 25 ℃; for 12h;
DOI:10.1081/NCN-100001435

Reference yield:

: 1435-44-5
1-chloro-2,4-difluorobenzene

: 333447-50-0
1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-5-chloro-2,4-difluorobenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: 87 percent / N-iodosuccinimide / trifluoromethanesulfonic acid / 2 h / 25 °C

2.1: Mg; I₂ / tetrahydrofuran / 1 h / 40 °C

2.2: CdCl₂ / 1 h / Heating

2.3: 33 percent / 12 h / 25 °C

With N-iodo-succinimide; iodine; magnesium; In tetrahydrofuran; trifluorormethanesulfonic acid;
DOI:10.1081/NCN-100001435

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 333447-50-0
1-(3,5-bis-O-(p-chlorobenzoyl)-2'-deoxy-α-D-ribofuranosyl)-5-chloro-2,4-difluorobenzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: AcCl; MeOH / 0.75 h / 25 °C

1.2: pyridine; DMAP / 0 - 25 °C

1.3: 82 percent / HCl gas / diethyl ether; acetic acid / 0.17 h / 0 °C

2.1: Mg; I₂ / tetrahydrofuran / 1 h / 40 °C

2.2: CdCl₂ / 1 h / Heating

2.3: 33 percent / 12 h / 25 °C

With methanol; iodine; magnesium; acetyl chloride; In tetrahydrofuran;
DOI:10.1081/NCN-100001435