7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide

Base Information

Chemical Name:7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide
CAS No.:229003-49-0
Molecular Formula:C₃₀H₃₂N₂O
Molecular Weight:436.597
Hs Code.:

Synonyms:7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide

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Chemical Property of 7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide

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Technology Process of 7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide

There total 12 articles about 7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 29608-05-7
1-(4-aminobenzyl)piperidine

: 7-p-tolyl-3,4-dihydro-naphthalene-2-carbonyl chloride

: 229003-49-0
7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm9906264

Reference yield:

: 79-37-8
oxalyl dichloride

: 29608-05-7
1-(4-aminobenzyl)piperidine

: 229006-60-4
7-(4-methyl-phenyl)-3,4-dihydronaphthalene-2-carboxylic acid

: 229003-49-0
7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 110-89-4
piperidine

: 229003-49-0
7-(4-methylphenyl)-N-[4-(piperidinomethyl)phenyl]-3,4-dihydronaphthalene-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / tetrahydrofuran / 20 °C

2: 75 percent / H₂ / 10percent Pd/C / ethyl acetate / 2 h / 20 °C

3: 75 percent / Et₃N / tetrahydrofuran / 20 °C

With hydrogen; triethylamine; 10percent Pd/C; In tetrahydrofuran; ethyl acetate; 1: benzylation / 2: Catalytic hydrogenation / 3: Acylation;
DOI:10.1021/jm9906264