4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazole

Base Information

• Chemical Name: 4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazole
• CAS No.: 152628-02-9
• Molecular Formula: C19H20N4
• Molecular Weight: 304.395
• Hs Code.: 2933990090
• European Community (EC) Number: 440-240-7,604-866-6
• UNII: 6LS25C273E
• DSSTox Substance ID: DTXSID20165089
• Nikkaji Number: J2.826.563H
• Wikidata: Q27265122
• Mol file: 152628-02-9.mol

Synonyms:152628-02-9;2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl)benzimidazole;4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazole;1,7'-DIMETHYL-2'-PROPYL-1H,1'H-2,5'-BIBENZO[D]IMIDAZOLE;2,5'-BI-1H-BENZIMIDAZOLE, 1,7'-DIMETHYL-2'-PROPYL-;1,7'-Dimethyl-2'-propyl-2,5'-bibenzimidazole;4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propyl-1H-benzimidazole;UNII-6LS25C273E;1,7'-DIMETHYL-2'-PROPYL-1H,3'H-2,5'-BIBENZO[D]IMIDAZOLE;2-PROPYL-4-METHYL-6-(1-METHYLBENZIMIDAZOL-2-YL)BENZIMIDAZOLE;6LS25C273E;MFCD03840857;N-Des((4-(2-carboxyphenyl)phenyl)methyl) telmisartan;Telmisartan specified impurity A [EP];1,7'-Dimethyl-2'-propyl-1H,3'H-2,5'-bibenzo(d)imidazole;2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazole;4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazole;Telmisartan EP Impurity A;SCHEMBL159014;SCHEMBL5819981;DTXSID20165089;ILXRSCZVHSZGCS-UHFFFAOYSA-N;BCP22453;AKOS015839597;AKOS015888106;AB16750;AM90296;BCP9000111;CS-O-08258;CS-W019361;DS-0263;AC-19086;SY110551;BCP0726000060;D5079;FT-0643496;TELMISARTAN IMPURITY A [EP IMPURITY];EN300-6764215;Q-200320;1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazole];Q27265122;1,4'-Dimethyl-2'-propyl-2,6'-bi[1H-benzoimidazole];1,7'-dimethyl-2'-propyl-1h,3'h-[2,5']bibenzoimidazolyl;2-(1-propyl)-4-methyl-6-(1'-methylbenzimidazol-2-yl)benzimidazole;2-n-Propyl-4-Methyl-6-(1'-Methylbenzimidazole-2-yl) Benzimidazole;2-n-propyl-4-methyl-6-(1-methyl benzimidazole-2-yl)benzimidazole;2-n-Propyl-4-methyl-6-(1-methylbenzimidazole-2-yl) benzimidazole;1H-Benzimidazole-2-n-propyl-4-methyl-6-(1'-methyl benzimidazole-2'-yl);1H-Benzimidazole-2-n-propyl-4-methyl-6-(1'methyl benzimidazole-2'-yl);4-METHYL-6-(1-METHYLBENZIMIDAZOL-2-YL)-2-PROPYLBENZIMIDAZOLE;4-methyl-6-(1-methyl-1H-benzo[d]imidazol-2-yl)-2-propyl-1H-benzo[d]-imidazole;4-Methyl-6-(1-methyl-1H-benzo[d]imidazol-2-yl)-2-propyl-1H-benzo[d]imidazole;1,7 inverted exclamation mark -Dimethyl-2 inverted exclamation mark -propyl-1H,3 inverted exclamation mark H-2,5 inverted exclamation mark -bibenzo[d]imidazole

Chemical Property of 4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazole

Chemical Property:

• Appearance/Colour: grey powder
• Vapor Pressure: 0-0Pa at 20-25℃
• Melting Point: 130-135 °C(Solv: tetrahydrofuran (109-99-9))
• Boiling Point: 584.802 °C at 760 mmHg
• PKA: 11.86±0.30(Predicted)
• Flash Point: 307.477 °C
• PSA: 46.50000
• Density: 1.23 g/cm³
• LogP: 4.37750
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 304.16879665
• Heavy Atom Count: 23
• Complexity: 414

Purity/Quality:

≥98.0% ^*data from raw suppliers

2-n-Propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCCC1=NC2=C(N1)C=C(C=C2C)C3=NC4=CC=CC=C4N3C
• Uses: An impurity found in Telmisartan (T017000).

Technology Process of 4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazole

There total 60 articles about 4-Methyl-6-(1-methyl-1H-benzimidazol-2-yl)-2-propyl-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-methylbenzene-1,2-diamine dihydrochloride (25148-68-9) + 4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid (152628-03-0) → 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole (152628-02-9)

Guidance literature:

With methanesulfonic acid; In i-Amyl alcohol; at 130 - 135 ℃; for 18h; Temperature; Solvent; Reagent/catalyst;

Reference yield: 93.0%

C19H21IN4 → 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole (152628-02-9)

Guidance literature:

With copper(l) iodide; caesium carbonate; In dimethyl sulfoxide; at 130 ℃;

DOI:10.1039/d0ra00886a

Reference yield: 92.0%

C19H21BrN4 → 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole (152628-02-9)

Guidance literature:

With copper(l) iodide; caesium carbonate; In dimethyl sulfoxide; at 130 ℃;

DOI:10.1039/d0ra00886a

upstream raw materials:

N-methylbenzene-1,2-diamine dihydrochloride

4-methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid

methyl 4-amino-3-methylbenzoate

methyl 4-(n-butyrylamino)-3-methylbenzoate

Downstream raw materials:

C₂₈H₂₇BrN₄

3'-([2'-(4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl)biphenyl-4-yl]methyl)-1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazole

4'-(1,4'-dimethyl-2'-propyl-1H-[2,5']dibenzimidazolyl-3'-ylmethyl)biphenyl-2-carboxylic acid methyl ester hydrochloride

Refernces

• 1、 -. "Compound based on benzimidazole substituted halogenated phenyl n-butylamidine and preparation method of compound". Paragraph 0146; 0147; 0154; 0155. . Retrieved 2021/04/29.
• 2、 Zhao, Jianhong,Xiong, Yicheng,Yang, Wu-Lin,Yang, Fan,Jin, Yu. "Highly Efficient and Practical Synthesis of the Key Intermediate of Telmisartan". . p. 1022 - 1027. Retrieved 2021/04/12.