1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-ethoxymethylphenyl)-1-butene

Base Information

Chemical Name:1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-ethoxymethylphenyl)-1-butene
CAS No.:443147-33-9
Molecular Formula:C₁₈H₂₄Br₂O₃
Molecular Weight:448.195
Hs Code.:

Synonyms:1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-ethoxymethylphenyl)-1-butene

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Chemical Property of 1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-ethoxymethylphenyl)-1-butene

Chemical Property:

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Technology Process of 1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-ethoxymethylphenyl)-1-butene

There total 8 articles about 1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-ethoxymethylphenyl)-1-butene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 558-13-4
carbon tetrabromide

: 443147-23-7
2-(S)-tetrahydropyranyloxy-3-(3-ethoxymethylphenyl)propan-1-al

: 443147-33-9
1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-ethoxymethylphenyl)-1-butene

Guidance literature:: With triethylamine; triphenylphosphine; In dichloromethane; at -40 ℃;
DOI:10.1016/S0968-0896(02)00031-7

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 443147-33-9
1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-ethoxymethylphenyl)-1-butene

Guidance literature:: Multi-step reaction with 4 steps

1: p-TsOH*H₂O / CH₂Cl₂ / 20 °C

2: 51 percent / 2N NaOH / methanol / 20 °C

3: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -70 - -30 °C

4: PPh₃; Et₃N / CH₂Cl₂ / -40 °C

With sodium hydroxide; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; In methanol; dichloromethane;
DOI:10.1016/S0968-0896(02)00031-7

Reference yield:

: 95068-01-2
1-bromo-3-(ethoxymethyl)benzene

: 443147-33-9
1,1-dibromo-3-(S)-tetrahydropyranyloxy-4-(3-ethoxymethylphenyl)-1-butene

Guidance literature:: Multi-step reaction with 7 steps

1.1: Mg; CuI / tetrahydrofuran / 0 °C

1.2: 95 percent / tetrahydrofuran

2.1: AcOH; H₂O / tetrahydrofuran / 65 °C

3.1: 2,4,6-collidine / CH₂Cl₂ / -78 °C

4.1: p-TsOH*H₂O / CH₂Cl₂ / 20 °C

5.1: 51 percent / 2N NaOH / methanol / 20 °C

6.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -70 - -30 °C

7.1: PPh₃; Et₃N / CH₂Cl₂ / -40 °C

With 2,4,6-trimethyl-pyridine; sodium hydroxide; copper(l) iodide; oxalyl dichloride; water; toluene-4-sulfonic acid; magnesium; acetic acid; dimethyl sulfoxide; triethylamine; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0968-0896(02)00031-7