Ethyl candesartan

Base Information Edit

Chemical Name:Ethyl candesartan
CAS No.:139481-58-6
Molecular Formula:C26H24N6O3
Molecular Weight:468.515
Hs Code.:
European Community (EC) Number:642-256-1
UNII:8TT2Y1F36J
DSSTox Substance ID:DTXSID50161059
Wikidata:Q27270999
Mol file:139481-58-6.mol

Synonyms:Candesartan Ethyl Ester;139481-58-6;Ethyl candesartan;ethyl 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate;UNII-8TT2Y1F36J;8TT2Y1F36J;Candesartan Cilexetil EP Impurity A;ethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate;Candesartan cilexetil impurity A [EP];EC 642-256-1;Candesartan cilexetil specified impurity A [EP];Ethyl 1-((2'-(1H -tetrazol-5-yl)biphenyl-4-yl)methyl(-2-ethoxybenzimidazole-7-carboxylate;Ethyl 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-1H-benzimidazole-7-carboxylate;1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, ethyl ester;1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, ethyl ester;Ethyl 1-((2'-(1H-tetrazol-5-yl)-(1,1'-biphenyl)-4-yl)methyl)-2-ethoxy-1H-benzo(d)imidazole-7-carboxylate;ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate;Ethyl 2-Ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate;SCHEMBL683298;DTXSID50161059;BCPWNYREAURMOP-UHFFFAOYSA-N;AMY22169;BCP07078;Ethyl -2-ethoxy-1-[[(2-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl];AKOS015964210;CS-O-07479;ethyl 2-ethoxy-1-[[(2'-(1h-tetrazol-5-yl)biphenyl-4-yl)methyl]benzimidazole]-7-carboxylate;AC-18527;AS-58069;Ethyl -2-ethoxy-1-[[(2 inverted exclamation marka-(1Htetrazol-5-yl)biphenyl-4-yl-) methyl]benzimidazole]-7-carboxylate;FT-0664224;D95996;L006258;A1-01748;J-007280;CANDESARTAN CILEXETIL IMPURITY A [EP IMPURITY];Q27270999;Ethyl-2-ethoxy-1-[[(2-(1htetrazol-5-yl)biphenyl-4-yl-)methyl];ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl) biphenyl-4-yl]methyl]benzimidazole-7-carboxylate;ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylate;Ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate;ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-benzimidazole-7-carboxylate;Ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazoie-7-carboxylate;ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate;Ethyl 2-ethoxy-l-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate;ethyl 2-ethoxy-l-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate;(ETHYL 1-{[2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL]METHYL-2-ETHOXYBENZIMIDAZOLE-7-CARBOXYLATE);Ethyl 2-ethoxy-1-[[2'-(1 H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate;ethyl 2-ethoxy-1-[[2'-(1 H-tetrazol-5-yl)biphenyl-4-yl]methyl]-benzimidazole-7-carboxylate;ethyl 2-ethoxy-1-{[2'-(1H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylate;ethyl 2-ethoxy-1-{[2'-(2H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-1,3-benzodiazole-7-carboxylate;ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

Suppliers and Price of Ethyl candesartan

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 97%
100g
$ 580.00

Crysdot
Ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 97%
10g
$ 100.00

Crysdot
Ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 97%
5g
$ 60.00

Crysdot
Ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 97%
25g
$ 190.00

Biosynth Carbosynth
Candesartan ethyl ester
100 mg
$ 1529.00

Biosynth Carbosynth
Candesartan ethyl ester
50 mg
$ 841.50

Biosynth Carbosynth
Candesartan ethyl ester
5 mg
$ 140.00

Biosynth Carbosynth
Candesartan ethyl ester
10 mg
$ 254.50

Biosynth Carbosynth
Candesartan ethyl ester
25 mg
$ 463.00

American Custom Chemicals Corporation
CANDESARTAN CILEXETILE EP IMPURITY A 95.00%
5MG
$ 452.25

Total 111 raw suppliers

Chemical Property of Ethyl candesartan Edit

Chemical Property:

Appearance/Colour:Off-White Solid
Melting Point:157-159 °C
Boiling Point:709.56 °C at 760 mmHg
PKA:4.15±0.10(Predicted)
Flash Point:382.928 °C
PSA：107.81000
Density:1.335 g/cm³
LogP:4.50710
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly, Sonicated), Methanol (Slightly)
XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:9
Exact Mass:468.19098865
Heavy Atom Count:35
Complexity:690

Purity/Quality:

99% ^*data from raw suppliers

Ethyl1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OCC
Uses Candesartan Ethyl Ester (Candesartan Cilexetil EP Impurity A) is a Candesartan analog, an angiotensin II antagonist. Candesartan analog as angiotensin II antagonist.

Technology Process of Ethyl candesartan

There total 10 articles about Ethyl candesartan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 916891-91-3
ethyl 2-ethoxy-1-[[2'-[(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-[1,1']biphenyl-4-yl]methyl]-1H-benzoimidazole-7-carboxylate

: 139481-58-6
ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate

Guidance literature:: With sodium formate; palladium 10% on activated carbon; In ethanol; for 72h; Product distribution / selectivity; Heating / reflux;

Reference yield: 45.0%

1N-HCl: 1N-HCl

: 139481-41-7
ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

: 1118-03-2
trimethyltin azide

: 139481-58-6
ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate

Guidance literature:: With sodium hydroxide; In methanol; toluene;

Reference yield: 39.9%

: 854538-88-8
ethyl 1-(4-bromobenzyl)-2-ethoxy-benzimidazole-7-carboxylate

: 155884-01-8
(2-(2H-tetrazol-5-yl)phenyl)boronic acid

: 139481-58-6
ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate

Guidance literature:: With potassium carbonate; palladium diacetate; triphenylphosphine; In water; toluene; at 60 - 70 ℃; for 16h; Product distribution / selectivity;