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Hydroxychloroquine sulfate

Base Information Edit
  • Chemical Name:Hydroxychloroquine sulfate
  • CAS No.:747-36-4
  • Molecular Formula:C18H26ClN3O*H2O4S
  • Molecular Weight:433.956
  • Hs Code.:29334990
  • European Community (EC) Number:212-019-3
  • NSC Number:758663,4375
  • UNII:8Q2869CNVH
  • DSSTox Substance ID:DTXSID1047811
  • Wikidata:Q27270879
  • NCI Thesaurus Code:C29101
  • RXCUI:153972
  • ChEMBL ID:CHEMBL1690
  • Mol file:747-36-4.mol
Hydroxychloroquine sulfate

Synonyms:Hydroxychlorochin;Hydroxychloroquine;Hydroxychloroquine Sulfate;Hydroxychloroquine Sulfate (1:1) Salt;Oxychlorochin;Oxychloroquine;Plaquenil

Suppliers and Price of Hydroxychloroquine sulfate
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Hydroxychloroquine Sulfate
  • 10g
  • $ 247.00
  • TRC
  • Hydroxychloroquine Sulfate
  • 5mg
  • $ 75.00
  • Tocris
  • Hydroxychloroquine Sulfate ≥99%(HPLC)
  • 10
  • $ 98.00
  • Tocris
  • Hydroxychloroquine Sulfate ≥99%(HPLC)
  • 50
  • $ 410.00
  • TCI Chemical
  • Hydroxychloroquine Sulfate >98.0%(HPLC)(N)
  • 25g
  • $ 225.00
  • TCI Chemical
  • Hydroxychloroquine Sulfate >98.0%(HPLC)(N)
  • 5g
  • $ 68.00
  • Sigma-Aldrich
  • Hydroxycloroquine sulfate analytical standard
  • 50mg
  • $ 49.00
  • Sigma-Aldrich
  • Hydroxychloroquine sulfate ≥98% (HPLC), powder
  • 5mg
  • $ 113.00
  • Sigma-Aldrich
  • Hydroxychloroquine sulfate Pharmaceutical Secondary Standard; Certified Reference Material
  • 1g
  • $ 199.00
  • Sigma-Aldrich
  • Hydroxychloroquine sulfate United States Pharmacopeia (USP) Reference Standard
  • 200mg
  • $ 366.00
Total 204 raw suppliers
Chemical Property of Hydroxychloroquine sulfate Edit
Chemical Property:
  • Appearance/Colour:White cyrstalline solid 
  • Vapor Pressure:1.68E-11mmHg at 25°C 
  • Melting Point:240 °C 
  • Boiling Point:516.7 °C at 760 mmHg 
  • Flash Point:266.3 °C 
  • PSA:131.37000 
  • LogP:4.28400 
  • Storage Temp.:Refrigerator 
  • Solubility.:H2O: >20mg/mL 
  • Water Solubility.:FREELY SOLUBLE 
  • Hydrogen Bond Donor Count:4
  • Hydrogen Bond Acceptor Count:8
  • Rotatable Bond Count:9
  • Exact Mass:433.1438199
  • Heavy Atom Count:28
  • Complexity:413
Purity/Quality:

99% *data from raw suppliers

Hydroxychloroquine Sulfate *data from reagent suppliers

Safty Information:
  • Pictogram(s): HarmfulXn, IrritantXi 
  • Hazard Codes:Xn,Xi 
  • Statements: 42/43-36/37/38-36-22 
  • Safety Statements: 37/39-26 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O
  • Recent ClinicalTrials:LY3214996 +/- HCQ in Pancreatic Cancer
  • Recent EU Clinical Trials:Prospective, randomized, double-blind, placebo-controlled, single-center comparative trial evaluating oral hydroxychloroquine 200 mg BID for reducing microglial activation in the brain of patients with progressive multiple sclerosis (MS)
  • Recent NIPH Clinical Trials:Prohylaxis with hydroxichloroquine aiming at prevention of COVID-19 for medical care workers
  • Description Hydroxychloroquine sulfate (also known as hydroxychloroquine) is an antimalarial medicine approved in the United States for either prevention or treatment of certain types of malaria, lupus erythematosus, and rheumatoid arthritis. It is sold under the brand name Plaquenil and it is also sold as a generic medicine. It is available in tablets of 155mg base (200mg salt). Hydroxychloroquine sulfate has not been approved for the treatment of COVID-19. It has been used experimentally to treat certain people with COVID-19, including hospitalized patients. Hydroxychloroquine sulfate is being used to try and stop the COVID-19 virus from spreading inside your body. This may help you to get better. Hydroxychloroquine sulfate is experimental because we do not know if it works for COVID-19. It is not approved by FDA for the treatment of COVID-19, but emergency use has been authorized for adults and adolescents who weigh 50 kg (110 pounds) or more and are hospitalized with COVID-19 if a clinical trial is not available or you are not able to participate in a clinical trial. There is limited information known about the safety and effectiveness (whether this will make you better) of using hydroxychloroquine sulfate for hospitalized patients with COVID-19. Hydroxychloroquine is an aminoquinoline with antimalarial, anti-inflammatory, and antiviral activities. It is active against the chloroquine-sensitive NF54 and D6 strains of P. falciparum (IC50s = 16.3 and 15 nM, respectively) but has decreased activity against chloroquine-resistant P. falciparum strains (IC50s = 422.7-1,735.3 nM). Hydroxychloroquine inhibits production of IL-22, IL-17A, and IL-6 induced by phorbol 12-myristate 13-acetate (TPA; ) and ionomycin in peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals or patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA). It inhibits accumulation of sequestosome-1 (SQSTM1) puncta, a marker of autophagy, in mouse embryonic fibroblasts (MEFs) in a concentration-dependent manner. Hydroxychloroquine reduces viral titers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the culture supernatant of infected Vero E6 cells but does not reduce SARS-CoV-2 viral titers in an in vitro human airway epithelium model or the respiratory tract of infected cynomolgus macaques. Formulations containing hydroxychloroquine have been used in the prevention or treatment of malaria, as well as in the treatment of RA and SLE.
  • Uses Hydroxychloroquine Sulfate can be used as a pharmaceutical secondary standard for the determination of the analyte in pharmaceutical formulations, and biological samples by various analytical techniques.These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. antimalarial, lupus suppressant
  • Clinical Use Hydroxychloroquine sulfate is highly water soluble and exists in two different forms of different melting points. It is readily absorbed on oral administration, reaching peak plasma levels within 1 to 3 hours. It concentrates in organs such as the liver, spleen, kidneys, heart, lung, and brain, thereby prolonging elimination. Hydroxychloroquine is metabolized by N-dealkylation of the tertiary amines, followed by oxidative deamination of the resulting primary amine to the carboxylic acid derivative. In addition to possessing corneal and renal toxicity, hydroxychloroquine also may cause CNS, neuromuscular, GI, and hematological side effects. Hydroxychloroquine sulfate is indicated for the treatment of rheumatoid arthritis, lupus erythematosus, and malaria.
  • Drug interactions Anti-arrhythmics: increased risk of ventricular arrhythmias when hydroxychloroquine administered with amiodarone – avoid concomitant use Digoxin: Hydroxychloroquine sulfate has been reported to increase plasma digoxin levels: serum digoxin levels should be closely monitored in patients receiving concomitant therapy. Antibacterials: increased risk of ventricular arrhythmias when hydroxychloroquine administered with moxifloxacin – avoid concomitant use. Ciclosporin: hydroxychloroquine increases plasma concentration of ciclosporin (increased risk of toxicity) . Antacids: as with chloroquine, antacids may reduce absorption of hydroxychloroquine so it is advised that a 4 hour interval be observed between hydroxychloroquine and antacid dosaging. Antidiabetic medicines: As hydroxychloroquine may enhance the effects of hypoglycaemic treatment, a decrease in doses of insulin or antidiabetic drugs may be required. Tamoxifen: may enhance the adverse/toxic effect of Hydroxychloroquine. Specifically, concomitant use of tamoxifen and hydroxychloroquine may increase the risk of retinal toxicity.
Technology Process of Hydroxychloroquine sulfate

There total 21 articles about Hydroxychloroquine sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With sulfuric acid; In water; at 15 - 55 ℃; for 5h; Temperature; Solvent;

Reference yield: 93.8%

Guidance literature:
With sulfuric acid; In ethanol; at 50 - 60 ℃; for 1h;
Guidance literature:
With sulfuric acid; In ethanol; at 60 ℃; for 1h;
Refernces Edit
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