Hydroxychloroquine

Base Information Edit

Chemical Name:Hydroxychloroquine
CAS No.:118-42-3
Deprecated CAS:117456-74-3,25526-45-8
Molecular Formula:C18H26ClN3O
Molecular Weight:335.877
Hs Code.:3004390090
European Community (EC) Number:204-249-8
UNII:4QWG6N8QKH
DSSTox Substance ID:DTXSID8023135
Nikkaji Number:J5.298A
Wikipedia:Hydroxychloroquine
Wikidata:Q421094
NCI Thesaurus Code:C557
RXCUI:5521
Pharos Ligand ID:DTMVCQWRY5XU
Metabolomics Workbench ID:43596
ChEMBL ID:CHEMBL1535
Mol file:118-42-3.mol

Synonyms:Hydroxychlorochin;Hydroxychloroquine;Hydroxychloroquine Sulfate;Hydroxychloroquine Sulfate (1:1) Salt;Oxychlorochin;Oxychloroquine;Plaquenil

Suppliers and Price of Hydroxychloroquine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Hydroxychloroquine
10mg
$ 360.00

TRC
Hydroxychloroquine
50mg
$ 320.00

CSNpharm
Hydroxychloroquine
100mg
$ 45.00

ChemScene
Hydroxychloroquine
25g
$ 148.00

ChemScene
Hydroxychloroquine
10g
$ 70.00

ChemScene
Hydroxychloroquine
100g
$ 499.00

American Custom Chemicals Corporation
HYDROXYCHLOROQUINE 95.00%
5MG
$ 501.81

Ambeed
2-((4-((7-Chloroquinolin-4-yl)amino)pentyl)(ethyl)amino)ethanol 98+%
250mg
$ 8.00

AK Scientific
Hydroxychloroquine
1g
$ 937.00

Total 95 raw suppliers

Chemical Property of Hydroxychloroquine Edit

Chemical Property:

Vapor Pressure:1.68E-11mmHg at 25°C
Melting Point:89-91°
Refractive Index:1.5790 (estimate)
Boiling Point:516.673 °C at 760 mmHg
PKA:14.76±0.10(Predicted)
Flash Point:266.275 °C
PSA：48.39000
Density:1.177 g/cm³
LogP:3.85600
Storage Temp.:Keep in dark place,Sealed in dry,Room Temperature
Solubility.:Chloroform (Slightlly), DMSO (Slightly), Methanol (Slightly)
XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:335.1764402
Heavy Atom Count:23
Complexity:331

Purity/Quality:

98% ^*data from raw suppliers

Hydroxychloroquine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Drug Classes:Antirheumatic Agents
Canonical SMILES:CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO
Recent ClinicalTrials:Trial of Ulixertinib in Combination With Hydroxychloroquine in Patients With Advanced Gastrointestinal (GI) Malignancies
Recent EU Clinical Trials:NEw Clinical End-points in patients with primary Sj?gren’s Syndrome (pSS): an Interventional Trial based on stratifYing patients
Recent NIPH Clinical Trials:Randomized , double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of belimumab for early systemic lupus erythematosus
description Hydroxychloroquine is a synthetic antimalarial agent which can also inhibit Toll-like receptor 7/9 (TLR7/9) signaling. Hydroxychloroquine is efficiently inhibits SARS-CoV-2 infection in vitro.Hydroxychloroquine, an analogue of chloroquine, was developed in 1946. Hydroxychloroquine and chloroquine are FDA-approved to treat or prevent malaria. Hydroxychloroquine is also FDA-approved to treat autoimmune conditions such as chronic discoid lupus erythematosus, systemic lupus erythematosus in adults, and rheumatoid arthritis.Hydroxychloroquine is often taken in combination with other drugs such as methotrexate.
Uses Hydroxychloroquine is used to treat autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis, in addition to malaria.Hydroxychloroquine is a disease-modifying anti-rheumatic drug (DMARD). It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms.Hydroxychloroquine is used to treat:rheumatoid arthritisdiscoid and systemic lupus erythematosus (SLE)juvenile idiopathic arthritis (JIA).Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. If you have lupus, it may also improve the rash. It may be as long as 12 weeks before you notice the benefits.
Indications Hydroxychloroquine (Plaquenil), like chloroquine, is a 4-aminoquinoline derivative used for the suppressive and acute treatment of malaria. It also has been used for rheumatoid arthritis and discoid and systemic lupus erythematosus. Hydroxychloroquine has not been proved to be more effective than chloroquine. Adverse reactions associated with its use are similar to those described for chloroquine.The drug should not be used in patients with psoriasis or porphyria, since it may exacerbate these conditions.
Therapeutic Function Antimalarial
Clinical Use Hydroxychloroquine is approved for the treatment of both systemic and cutaneous lupus erythematosus. Both chloroquine and quinacrine (Atabrine) are also effective in this skin disease. Low-dose chloroquine is used for the therapy of porphyria cutanea tarda in patients in whom phlebotomy has failed or is contraindicated. Other skin diseases in which the drugs are useful (after sunscreens and avoidance of sun exposure) include polymorphous light eruption and solar urticaria.

Technology Process of Hydroxychloroquine

There total 14 articles about Hydroxychloroquine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%