α,α-bis(4-fluorophenyl)-1-<3-(phenylamino)propyl>-4-piperidinemethanol ethanedioate (1:2)

Base Information

Chemical Name:α,α-bis(4-fluorophenyl)-1-<3-(phenylamino)propyl>-4-piperidinemethanol ethanedioate (1:2)
CAS No.:117023-11-7
Molecular Formula:2C₂H₂O₄*C₂₇H₃₀F₂N₂O
Molecular Weight:616.616
Hs Code.:

Synonyms:α,α-bis(4-fluorophenyl)-1-<3-(phenylamino)propyl>-4-piperidinemethanol ethanedioate (1:2)

Suppliers and Price of α,α-bis(4-fluorophenyl)-1-<3-(phenylamino)propyl>-4-piperidinemethanol ethanedioate (1:2)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of α,α-bis(4-fluorophenyl)-1-<3-(phenylamino)propyl>-4-piperidinemethanol ethanedioate (1:2)

Chemical Property:

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Technology Process of α,α-bis(4-fluorophenyl)-1-<3-(phenylamino)propyl>-4-piperidinemethanol ethanedioate (1:2)

There total 6 articles about α,α-bis(4-fluorophenyl)-1-<3-(phenylamino)propyl>-4-piperidinemethanol ethanedioate (1:2) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 144-62-7,97993-78-7
oxalic acid

: 117023-92-4
4--N-phenyl-1-piperidinepropanamide

: 117023-11-7
α,α-bis(4-fluorophenyl)-1-<3-(phenylamino)propyl>-4-piperidinemethanol ethanedioate (1:2)

Guidance literature:: With lithium aluminium tetrahydride; 1) THF, reflux, 16 h;
DOI:10.1021/jm00121a022

Reference yield:

: 24228-40-8
N-benzyl isonipecotic acid ethyl ester

: 117023-11-7
α,α-bis(4-fluorophenyl)-1-<3-(phenylamino)propyl>-4-piperidinemethanol ethanedioate (1:2)

Guidance literature:: Multi-step reaction with 4 steps

1: 1) Mg / 1) THF, reflux, 15 min.; 2) THF, room temperature, overnight

2: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

3: 59 percent / Na₂CO₃, KI / dimethylformamide / 16 h / Heating

4: 45 percent / 1) LiAlH₄ / 1) THF, reflux, 16 h

With lithium aluminium tetrahydride; hydrogen; sodium carbonate; magnesium; potassium iodide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00121a022

Reference yield:

: 111627-25-9
α,α-bis-(4-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol

: 117023-11-7
α,α-bis(4-fluorophenyl)-1-<3-(phenylamino)propyl>-4-piperidinemethanol ethanedioate (1:2)

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂ / 5percent Pd/C / ethanol / 48 h / 70 °C / 2585.7 Torr

2: 59 percent / Na₂CO₃, KI / dimethylformamide / 16 h / Heating

3: 45 percent / 1) LiAlH₄ / 1) THF, reflux, 16 h

With lithium aluminium tetrahydride; hydrogen; sodium carbonate; potassium iodide; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00121a022