tert-butyl 4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybut-1-enyl]-2-methylbenzoate

Base Information

Chemical Name:tert-butyl 4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybut-1-enyl]-2-methylbenzoate
CAS No.:1425942-94-4
Molecular Formula:C₂₂H₂₁Cl₂F₃O₃
Molecular Weight:461.308
Hs Code.:

Synonyms:tert-butyl 4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybut-1-enyl]-2-methylbenzoate

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Chemical Property of tert-butyl 4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybut-1-enyl]-2-methylbenzoate

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Technology Process of tert-butyl 4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybut-1-enyl]-2-methylbenzoate

There total 2 articles about tert-butyl 4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybut-1-enyl]-2-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 445003-37-2
4-bromo-2-methyl-benzoic acid tert-butyl ester

: 1425942-93-3
2-(3,5-dichlorophenyl)-1,1,1-trifluoro-but-3-en-2-ol

: 1425942-94-4
tert-butyl 4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybut-1-enyl]-2-methylbenzoate

Guidance literature:: 4-bromo-2-methyl-benzoic acid tert-butyl ester; With tetrabutylammonium acetate; palladium diacetate; at 80 ℃; for 0.25h; Inert atmosphere;

2-(3,5-dichlorophenyl)-1,1,1-trifluoro-but-3-en-2-ol; at 80 ℃; for 60h;

Reference yield:

: 130336-16-2
3,5-dichloro-2,2,2-trifluoroacetophenone

: 1425942-94-4
tert-butyl 4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybut-1-enyl]-2-methylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrahydrofuran / -75 - 20 °C

2.1: tetrabutylammonium acetate; palladium diacetate / 0.25 h / 80 °C / Inert atmosphere

2.2: 60 h / 80 °C

With tetrabutylammonium acetate; palladium diacetate; In tetrahydrofuran;

Reference yield: 100.0%

: 201230-82-2
carbon monoxide

: 1425942-94-4
tert-butyl 4-[(E)-3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybut-1-enyl]-2-methylbenzoate

: tert-butyl 4-[5-(3,5-dichlorophenyl)-2-hydroxy-5-(trifluoromethyl)tetrahydrofuran-3-yl]-2-methylbenzoate

Guidance literature:: With dicarbonylacetylacetonato rhodium (I); tris(2,4-di-tert-butylphenyl)phosphite; hydrogen; In toluene; at 100 ℃; for 20h; under 37503.8 Torr; Inert atmosphere;