5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

Base Information

Chemical Name:5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol
CAS No.:58780-17-9
Molecular Formula:C₁₉H₂₃NO₄
Molecular Weight:329.396
Hs Code.:

Synonyms:5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

Suppliers and Price of 5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

There total 5 articles about 5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 23180-28-1
6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline

: 1864-94-4
phenyl formate

: 58780-17-9
5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

Guidance literature:: In ethyl acetate; Heating;
DOI:10.1021/jo01303a045

Reference yield:

: 23180-27-0
1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 58780-17-9
5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / Li, NH₃ (liquid) / tetrahydrofuran; 2-methyl-propan-2-ol / 1) 4h -55 to -65 deg C 2) 1.5h -75 deg C

2: 94 percent / ethyl acetate / Heating

With ammonia; lithium; In tetrahydrofuran; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/jo01303a045

Reference yield:

: 74007-21-9
N-<2-(3-methoxyphenyl)ethyl>(3-hydroxy-4-methoxyphenyl)acetamide

: 58780-17-9
5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

Guidance literature:: Multi-step reaction with 3 steps

1: 2)Na(CN)BH₃ / 1) cyclization, neutralization to pH 4-5 with concentrated aqueous NH₃ 2) reduction with Na(CN)BH₃ in refluxing 65percent MeOH for 1.5h

2: 90 percent / Li, NH₃ (liquid) / tetrahydrofuran; 2-methyl-propan-2-ol / 1) 4h -55 to -65 deg C 2) 1.5h -75 deg C

3: 94 percent / ethyl acetate / Heating

With ammonia; lithium; sodium cyanoborohydride; In tetrahydrofuran; ethyl acetate; tert-butyl alcohol;
DOI:10.1021/jo01303a045