1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline
CAS No.:23180-27-0
Molecular Formula:C₁₈H₂₁NO₃
Molecular Weight:299.37
Hs Code.:

Synonyms:1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

There total 7 articles about 1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67-56-1
methanol

: 1275589-14-4
C₂₁H₂₃NO₅

: 23180-27-0
1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 23180-29-2
2-methoxy-5-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol

Guidance literature:: C₂₁H₂₃NO₅; With ammonia; lithium; In tetrahydrofuran; isopropyl alcohol; at -70 - -60 ℃; for 1.5h;

methanol; In tetrahydrofuran; isopropyl alcohol; at 20 ℃; for 2h; Cooling with ice; Inert atmosphere;

Reference yield:

: 1033384-69-8
C₂₀H₂₃NO₅

: 23180-27-0
1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

: 23180-29-2
2-methoxy-5-(6-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / toluene / 1 h / 20 °C

2.1: triethylamine / N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂ / acetonitrile / 16 h / 20 °C / Inert atmosphere

3.1: ammonia; lithium / isopropyl alcohol; tetrahydrofuran / 1.5 h / -70 - -60 °C

3.2: 2 h / 20 °C / Cooling with ice; Inert atmosphere

With ammonia; lithium; triethylamine; trichlorophosphate; [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; N-[(1S,2S)-2-amino-1,2-diphenylethyl]-4-methylbenzenesulfonamide; In tetrahydrofuran; isopropyl alcohol; toluene; acetonitrile; 1.1: Bischler-Napieralski Reaction / 3.1: Birch Reduction;

Reference yield:

: 74007-21-9
N-<2-(3-methoxyphenyl)ethyl>(3-hydroxy-4-methoxyphenyl)acetamide

: 23180-27-0
1-(3'-hydroxy-4'-methoxy-benzyl)-6-methoxy-1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium cyanoborohydride; Yield given. Multistep reaction; 1) cyclization, neutralization to pH 4-5 with concentrated aqueous NH₃ 2) reduction with Na(CN)BH₃ in refluxing 65percent MeOH for 1.5h;
DOI:10.1021/jo01303a045