23180-27-0

Upstream product

• 1131-94-8 homoisovanillic acid 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 1033384-69-8 C₂₀H₂₃NO₅ 
• 67-56-1 methanol 
• 1275589-14-4 C₂₁H₂₃NO₅ 
• 74007-21-9 N-<2-(3-methoxyphenyl)ethyl>(3-hydroxy-4-methoxyphenyl)acetamide 

Downstream Products

• 74007-25-3 1-(2-Bromo-5-hydroxy-4-methoxy-benzyl)-1,3,4,5,7,8-hexahydro-2H-isoquinolin-6-one 
• 74007-23-1 1-(2'-bromo-4'-methoxy-5'-hydroxybenzyl)-2-formyl-6-ketal-1,3,4,5,7,8-hexahydroisoquinoline 
• 74007-22-0 C₂₀H₂₅NO₅ 
• 74007-24-2 1-(2'-bromo-4'-methoxy-5'-hydroxybenzyl)-2-formyl-1,3,4,5,7,8-hexahydroisoquinolin-6-one 
• 54186-36-6 1-(2'-bromo-4'-methoxy-5'-hydroxybenzyl)-2-formyl-1,3,4,6,7,8-hexahydroisoquinolin-6-one 
• 54186-35-5 1-(2-bromo-5-hydroxy-4-methoxy-benzyl)-1,3,4,7,8,8a-hexahydro-2H-isoquinolin-6-one 
• 58780-17-9 5-(2-formyl-6-methoxy-1,2,3,4,5,8-hexahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol 
• 23180-28-1 6-methoxy-1-(3-hydroxy-4-methoxybenzyl)-1,2,3,4,5,8-hexahydroisoquinoline 

Relevant academic research and scientific papers

One-Pot Preparation of Hexahydroisoquinolines from Amides

The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.

S-tetrahydroprotoberberineoxidase, process for producing the same and use thereof

The invention relates to the enzyme S-tetrahydroprotoberberineoxidase, which oxidizes selectively S-tetrahydroprotoberberines and S-1-benzyl-1,2,3,4-tetrahydroisoquinoline in the presence of oxygen, resulting in the corresponding protoberberines and 1-ben

Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution

In a short total synthesis of morphinan compounds, derivatives of 1-benzyl-1,2,3,4-tetrahydroisoquinoline are produced. Certain of these compounds, although highly aromatic and functionalized, can be optically resolved. The optically active enantiomers can serve as important intermediates for both natural and unnatural opioids.

Synthetic Opium Alkaloids and Derivatives. A Short Total Synthesis of (+/-)-Dihydrothebainone, (+/-)-Dihydrocodeinone, and (+/-)-Nordihydrocodeinone as an Approach to a Practical Synthesis of Morphine, Codeine, and Congeners.

Racemic dihydrothebainone (19), nordihydrocodeinone (21), and dihydrocodeinone (22) were synthesized in high overall yield from 3-methoxyphenethylamine (4), via the key intermediate (+/-)-1-bromonordihydrothebainone (18); the route utilized unprotected ph