(1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid

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Chemical Name:(1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid
CAS No.:1242441-07-1
Molecular Formula:C₁₉H₁₆ClN₃O₂S
Molecular Weight:385.874
Hs Code.:

Synonyms:(1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid

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Chemical Property of (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid

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Technology Process of (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid

There total 8 articles about (1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1242441-17-3
(1S,2S)-ethyl 2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylate

: 1242441-07-1
(1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid

Guidance literature:: With water; potassium hydroxide; In acetonitrile; at 85 ℃; for 0.75h;
DOI:10.1021/ml4000996

Reference yield:

: 875479-34-8
ethyl trans-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1242441-07-1
(1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethylmagnesium bromide; zinc(II) chloride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

1.2: 4 h / Reflux

2.1: N-iodo-succinimide / dichloromethane / 16 h / 20 °C

3.1: potassium carbonate; copper(l) iodide / isopropyl alcohol / 16 h / 80 °C / Inert atmosphere

4.1: potassium hydroxide; water / acetonitrile / 0.75 h / 85 °C

With N-iodo-succinimide; copper(l) iodide; ethylmagnesium bromide; water; potassium carbonate; potassium hydroxide; zinc(II) chloride; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/ml4000996

Reference yield:

: 40771-41-3
2-mercapto-5-chloro-pyridine

: 1242441-07-1
(1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; copper(l) iodide / isopropyl alcohol / 16 h / 80 °C / Inert atmosphere

2: potassium hydroxide; water / acetonitrile / 0.75 h / 85 °C

With copper(l) iodide; water; potassium carbonate; potassium hydroxide; In isopropyl alcohol; acetonitrile;
DOI:10.1021/ml4000996