(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide

Base Information

Chemical Name:(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide
CAS No.:1242441-26-4
Molecular Formula:C₂₁H₂₁ClN₄OS
Molecular Weight:412.943
Hs Code.:

Synonyms:(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide

Suppliers and Price of (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Matrix Scientific
(1S,2S)-2-(4-(5-((5-Chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide 97%
1g
$ 11160.00

Total 1 raw suppliers

Chemical Property of (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

(1S,2S)-2-(4-(5-((5-Chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide 97% ^*data from reagent suppliers

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Technology Process of (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide

There total 8 articles about (1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1242441-07-1
(1S,2S)-2-(4-{5-[(5-chloropyridin-2-yl)thio]-1-methyl-1H-imidazol-4-yl}phenyl)cyclopropanecarboxylic acid

: 124-40-3
dimethyl amine

: 1242441-26-4
(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; at 80 ℃; for 0.5h;

Reference yield:

: 875479-34-8
ethyl trans-2-(4-bromophenyl)cyclopropane-1-carboxylate

: 1242441-26-4
(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethylmagnesium bromide; zinc(II) chloride / diethyl ether; tetrahydrofuran / 1 h / 20 °C

1.2: 4 h / Reflux

2.1: N-iodo-succinimide / dichloromethane / 16 h / 20 °C

3.1: potassium carbonate; copper(l) iodide / isopropyl alcohol / 16 h / 80 °C / Inert atmosphere

4.1: potassium hydroxide; water / acetonitrile / 0.75 h / 85 °C

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; 1,4-dioxane / 0.5 h / 80 °C

With N-iodo-succinimide; copper(l) iodide; ethylmagnesium bromide; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/ml4000996

Reference yield:

: 1242441-05-9
ethyl (1S,2S)-2-[4-(5-iodo-1-methyl-1H-imidazol-4-yl)phenyl]cyclopropanecarboxylate

: 1242441-26-4
(1S,2S)-2-(4-(5-((5-chloropyridin-2-yl)thio)-1-methyl-1H-imidazol-4-yl)phenyl)-N,N-dimethylcyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; copper(l) iodide / isopropyl alcohol / 16 h / 80 °C / Inert atmosphere

2: potassium hydroxide; water / acetonitrile / 0.75 h / 85 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; 1,4-dioxane / 0.5 h / 80 °C

With copper(l) iodide; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; isopropyl alcohol; acetonitrile;
DOI:10.1021/ml4000996