tert-butyl (1-(4-(6-(cyanomethyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate

Base Information

Chemical Name:tert-butyl (1-(4-(6-(cyanomethyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate
CAS No.:1313440-17-3
Molecular Formula:C₃₁H₃₂N₄O₃
Molecular Weight:508.62
Hs Code.:

Synonyms:tert-butyl (1-(4-(6-(cyanomethyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate

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Chemical Property of tert-butyl (1-(4-(6-(cyanomethyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate

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Technology Process of tert-butyl (1-(4-(6-(cyanomethyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate

There total 3 articles about tert-butyl (1-(4-(6-(cyanomethyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1313440-15-1
tert-butyl (1-(4-(5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate

: 590-17-0
cyanomethyl bromide

: 1313440-17-3
tert-butyl (1-(4-(6-(cyanomethyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: tert-butyl (1-(4-(5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

cyanomethyl bromide; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1313440-17-3
tert-butyl (1-(4-(6-(cyanomethyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 18 h / 80 °C / Inert atmosphere

2.1: ammonium acetate; acetic acid / 2 h / 100 °C / Inert atmosphere; Molecular sieve

3.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 0 °C

With ammonium acetate; sodium hydride; acetic acid; In N,N-dimethyl-formamide;

Reference yield:

: 1247897-74-0
tert-butyl (1-(4-(3-(dimethylamino)-2-phenylacryloyl)phenyl)cyclobutyl)carbamate

: 1313440-17-3
tert-butyl (1-(4-(6-(cyanomethyl)-5-oxo-3-phenyl-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)phenyl)cyclobutyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonium acetate; acetic acid / 2 h / 100 °C / Inert atmosphere; Molecular sieve

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 0 °C

With ammonium acetate; sodium hydride; acetic acid; In N,N-dimethyl-formamide;