propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluorophenyl]amide}, hydrochloric acid salt

Base Information

Chemical Name:propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluorophenyl]amide}, hydrochloric acid salt
CAS No.:1415041-85-8
Molecular Formula:C₂₃H₁₈ClF₂N₃O₃S*ClH
Molecular Weight:526.391
Hs Code.:

Synonyms:propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluorophenyl]amide}, hydrochloric acid salt

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Chemical Property of propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluorophenyl]amide}, hydrochloric acid salt

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Technology Process of propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluorophenyl]amide}, hydrochloric acid salt

There total 5 articles about propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluorophenyl]amide}, hydrochloric acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1029872-54-5,918504-65-1
vemurafenib

: 1415041-85-8
propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluorophenyl]amide}, hydrochloric acid salt

Guidance literature:: With hydrogenchloride; In diethyl ether; acetone; at 35 ℃; Solvent;

Reference yield:

: 918504-27-5
N-[3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide

: 1415041-85-8
propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluorophenyl]amide}, hydrochloric acid salt

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; tri-n-propylamine / toluene

2: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / toluene; water / 2 h / 25 - 110 °C / Inert atmosphere

3: ammonia / N,N-dimethyl-formamide; methanol / 18 h / 25 - 55 °C

4: hydrogenchloride / acetone; diethyl ether / 35 °C

With hydrogenchloride; tri-n-propylamine; dmap; bis-triphenylphosphine-palladium(II) chloride; ammonia; sodium carbonate; In methanol; diethyl ether; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1262985-24-9
propane-1-sulfonic acid {3-[5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}amide

: 1415041-85-8
propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluorophenyl]amide}, hydrochloric acid salt

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate; bis-triphenylphosphine-palladium(II) chloride / toluene; water / 2 h / 25 - 110 °C / Inert atmosphere

2: ammonia / N,N-dimethyl-formamide; methanol / 18 h / 25 - 55 °C

3: hydrogenchloride / acetone; diethyl ether / 35 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; ammonia; sodium carbonate; In methanol; diethyl ether; water; N,N-dimethyl-formamide; acetone; toluene;