(1''S,1'''S,3''''S)-5-methylisoxazole-3-carboxylic acid [1'-(2''-(3''',4'''-difluorophenyl)-1''-{1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]-2'''-hydroxyethylcarbamol}ethyl)-2'-oxo-1',2'-dihydropyridin-3'-yl]amide

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Chemical Name:(1''S,1'''S,3''''S)-5-methylisoxazole-3-carboxylic acid [1'-(2''-(3''',4'''-difluorophenyl)-1''-{1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]-2'''-hydroxyethylcarbamol}ethyl)-2'-oxo-1',2'-dihydropyridin-3'-yl]amide
CAS No.:422323-07-7
Molecular Formula:C₃₅H₃₇F₂N₅O₈
Molecular Weight:693.704
Hs Code.:

(1''S,1'''S,3''''S)-5-methylisoxazole-3-carboxylic acid [1'-(2''-(3''',4'''-difluorophenyl)-1''-{1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]-2'''-hydroxyethylcarbamol}ethyl)-2'-oxo-1',2'-dihydropyridin-3'-yl]amide

Synonyms:(1''S,1'''S,3''''S)-5-methylisoxazole-3-carboxylic acid [1'-(2''-(3''',4'''-difluorophenyl)-1''-{1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]-2'''-hydroxyethylcarbamol}ethyl)-2'-oxo-1',2'-dihydropyridin-3'-yl]amide

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Chemical Property of (1''S,1'''S,3''''S)-5-methylisoxazole-3-carboxylic acid [1'-(2''-(3''',4'''-difluorophenyl)-1''-{1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]-2'''-hydroxyethylcarbamol}ethyl)-2'-oxo-1',2'-dihydropyridin-3'-yl]amide

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Technology Process of (1''S,1'''S,3''''S)-5-methylisoxazole-3-carboxylic acid [1'-(2''-(3''',4'''-difluorophenyl)-1''-{1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]-2'''-hydroxyethylcarbamol}ethyl)-2'-oxo-1',2'-dihydropyridin-3'-yl]amide

There total 12 articles about (1''S,1'''S,3''''S)-5-methylisoxazole-3-carboxylic acid [1'-(2''-(3''',4'''-difluorophenyl)-1''-{1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]-2'''-hydroxyethylcarbamol}ethyl)-2'-oxo-1',2'-dihydropyridin-3'-yl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 422323-05-5
(1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}...

: 422323-07-7
(1''S,1'''S,3''''S)-5-methylisoxazole-3-carboxylic acid [1'-(2''-(3''',4'''-difluorophenyl)-1''-{1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]-2'''-hydroxyethylcarbamol}ethyl)-2'-oxo-1',2'-dihydropyridin-3'-yl]amide

Guidance literature:: With hydrogen fluoride; In acetonitrile; at 23 ℃; for 4.5h;
DOI:10.1021/jm010469k

Reference yield:

: 6332-56-5
2-hydroxy-3-nitropyridine

: 422323-07-7
(1''S,1'''S,3''''S)-5-methylisoxazole-3-carboxylic acid [1'-(2''-(3''',4'''-difluorophenyl)-1''-{1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]-2'''-hydroxyethylcarbamol}ethyl)-2'-oxo-1',2'-dihydropyridin-3'-yl]amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / 10percent Pd/C / ethanol / 16 h / 760.05 Torr

2.1: 65 percent / acetonitrile / 1.67 h / 0 - 23 °C

3.1: NaH / tetrahydrofuran / 0.33 h / 23 °C

3.2: 1.00 g / tetrahydrofuran / 16 h / Heating

4.1: 90 percent / aq. HF / acetonitrile / 4.5 h / 23 °C

With hydrogen fluoride; hydrogen; sodium hydride; 10percent Pd/C; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jm010469k

Reference yield:

: 33630-99-8
2-hydroxy-3-aminopyridine

: 422323-07-7
(1''S,1'''S,3''''S)-5-methylisoxazole-3-carboxylic acid [1'-(2''-(3''',4'''-difluorophenyl)-1''-{1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]-2'''-hydroxyethylcarbamol}ethyl)-2'-oxo-1',2'-dihydropyridin-3'-yl]amide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 65 percent / acetonitrile / 1.67 h / 0 - 23 °C

2.1: NaH / tetrahydrofuran / 0.33 h / 23 °C

2.2: 1.00 g / tetrahydrofuran / 16 h / Heating

3.1: 90 percent / aq. HF / acetonitrile / 4.5 h / 23 °C

With hydrogen fluoride; sodium hydride; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm010469k