(1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}...

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Chemical Name:(1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}...
CAS No.:422323-05-5
Molecular Formula:C₅₁H₅₅F₂N₅O₈Si
Molecular Weight:932.109
Hs Code.:

(1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}...

Synonyms:(1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}...

Suppliers and Price of (1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}...

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Chemical Property of (1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}...

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Technology Process of (1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}...

There total 11 articles about (1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6332-56-5
2-hydroxy-3-nitropyridine

: 422323-05-5
(1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}...

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / 10percent Pd/C / ethanol / 16 h / 760.05 Torr

2.1: 65 percent / acetonitrile / 1.67 h / 0 - 23 °C

3.1: NaH / tetrahydrofuran / 0.33 h / 23 °C

3.2: 1.00 g / tetrahydrofuran / 16 h / Heating

With hydrogen; sodium hydride; 10percent Pd/C; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1021/jm010469k

Reference yield:

: 343566-51-8
5-methylisoxazole-3-carboxylic acid (2'-hydroxypyridin-3'-yl)amide

: 422323-03-3
Methanesulfonic acid (R)-1-{(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-ylmethyl]-ethylcarbamoyl}-2-(3,4-difluoro-phenyl)-ethyl ester

: 422323-05-5
(1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}...

Guidance literature:: 5-methylisoxazole-3-carboxylic acid (2'-hydroxypyridin-3'-yl)amide; With sodium hydride; In tetrahydrofuran; at 23 ℃; for 0.333333h;

Methanesulfonic acid (R)-1-{(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-[(S)-1-(2,4-dimethoxy-benzyl)-2-oxo-pyrrolidin-3-ylmethyl]-ethylcarbamoyl}-2-(3,4-difluoro-phenyl)-ethyl ester; In tetrahydrofuran; for 16h; Further stages.; Heating;
DOI:10.1021/jm010469k

Reference yield:

: 33630-99-8
2-hydroxy-3-aminopyridine

: 422323-05-5
(1'''S,2''R,3''''S)-5-methylisoxazole-3-carboxylic acid {1'-[1''-{2'''-(tert-butyldiphenylsilanyloxy)-1'''-[1''''-(2''''',4'''''-dimethoxybenzyl)-2''''-oxopyrrolidin-3''''-ylmethyl]ethylcarbamol}-2''-(3'''''',4''''''-difluorophenyl)ethyl]-2'-...}...

Guidance literature:: Multi-step reaction with 2 steps

1.1: 65 percent / acetonitrile / 1.67 h / 0 - 23 °C

2.1: NaH / tetrahydrofuran / 0.33 h / 23 °C

2.2: 1.00 g / tetrahydrofuran / 16 h / Heating

With sodium hydride; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm010469k