2-(2,6-Dimethyl-4-oxo-cyclohex-2-enylmethyl)-malonic acid diethyl ester

Base Information

Chemical Name:2-(2,6-Dimethyl-4-oxo-cyclohex-2-enylmethyl)-malonic acid diethyl ester
CAS No.:76184-65-1
Molecular Formula:C₁₆H₂₄O₅
Molecular Weight:296.364
Hs Code.:

Synonyms:2-(2,6-Dimethyl-4-oxo-cyclohex-2-enylmethyl)-malonic acid diethyl ester

Suppliers and Price of 2-(2,6-Dimethyl-4-oxo-cyclohex-2-enylmethyl)-malonic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(2,6-Dimethyl-4-oxo-cyclohex-2-enylmethyl)-malonic acid diethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of 2-(2,6-Dimethyl-4-oxo-cyclohex-2-enylmethyl)-malonic acid diethyl ester

There total 1 articles about 2-(2,6-Dimethyl-4-oxo-cyclohex-2-enylmethyl)-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 59159-01-2
3,5-Dimethyl-4-methylene-2-cyclohexen-1-one

: 105-53-3
diethyl malonate

: 76184-65-1
2-(2,6-Dimethyl-4-oxo-cyclohex-2-enylmethyl)-malonic acid diethyl ester

Guidance literature:: With sodium; In ethanol; 1.) room temperature, 18 h, 2.) reflux, 15 min;

Reference yield:

: 76184-65-1
2-(2,6-Dimethyl-4-oxo-cyclohex-2-enylmethyl)-malonic acid diethyl ester

: 1460-73-7,19890-17-6,19890-18-7,23811-08-7,59331-07-6,59331-08-7,66537-53-9,121840-72-0,26934-83-8,4895-33-4
(±)-agarospirol

Guidance literature:: Multi-step reaction with 15 steps

1: 2 N hydrochloric acid / 20 h / Heating

2: 22 g / diethyl ether

3: 72 percent / p-toluenesulfonic acid / benzene / 40 h / Heating

4: 6 g / potassium hydroxide, water / 3 h / Heating

5: oxalyl chloride, pyridine / benzene / 2 h / Ambient temperature

6: 1.5 g / diethyl ether

7: copper / benzene / 3.5 h / Heating

8: 11.85 g / sodium hydride / 10.5 h / Heating

9: 3.47 g / sodium borohydride / methanol / 3 h / 0 °C

10: 80 percent / 1 N hydrochloric acid / methanol / 0.17 h / Ambient temperature

11: 77 percent / 1 N hydrochloric acid / 0.5 h / Ambient temperature

12: 62 percent / lithium tri-tert-butoxyaluminium hydride / diethyl ether / 4 h / Ambient temperature

13: 1.) magnesium / 1.) ether, 2.) ether, reflux, 2 h

14: 91 percent / pyridine / 3 h / Ambient temperature; in the dark

15: 92 percent / lithium, ethylamine / diethyl ether / 2.5 h

With pyridine; hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; oxalyl dichloride; lithium tri(t-butoxy)aluminum hydride; water; lithium; copper; sodium hydride; toluene-4-sulfonic acid; magnesium; ethylamine; In methanol; diethyl ether; benzene;

Reference yield:

: 76184-65-1
2-(2,6-Dimethyl-4-oxo-cyclohex-2-enylmethyl)-malonic acid diethyl ester

: 22196-19-6,76231-65-7,76231-66-8,138233-04-2
N-[(5S,10S)-6,10-Dimethyl-spiro[4.5]dec-6-en-(2Z)-ylidene]-N'-(2,4-dinitro-phenyl)-hydrazine

Guidance literature:: Multi-step reaction with 14 steps

1: 2 N hydrochloric acid / 20 h / Heating

2: 22 g / diethyl ether

3: 72 percent / p-toluenesulfonic acid / benzene / 40 h / Heating

4: 6 g / potassium hydroxide, water / 3 h / Heating

5: oxalyl chloride, pyridine / benzene / 2 h / Ambient temperature

6: 1.5 g / diethyl ether

7: copper / benzene / 3.5 h / Heating

8: 86 percent / 1 N hydrochloric acid / tetrahydrofuran / 1.5 h / 65 °C

9: 80 percent / p-toluenesulfonic acid / benzene / 4 h / Heating

10: 83 percent / lithium tri-tert-butoxyaluminium hydride / diethyl ether / 18 h / Ambient temperature

11: 395 mg / pyridine / 5 h / Ambient temperature; in the dark

12: 45 percent / lithium, liq. ammonia / diethyl ether / 2 h

13: 41 percent / water, p-toluenesulfonic acid / acetone / 5 h / Ambient temperature

14: 43 mg

With pyridine; hydrogenchloride; potassium hydroxide; oxalyl dichloride; lithium tri(t-butoxy)aluminum hydride; ammonia; water; lithium; copper; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; acetone; benzene;