1-chloro-4-(2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethylsulfinyl)benzene

Base Information

Chemical Name:1-chloro-4-(2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethylsulfinyl)benzene
CAS No.:1262638-55-0
Molecular Formula:C₁₈H₂₇ClO₂S
Molecular Weight:342.93
Hs Code.:

Synonyms:1-chloro-4-(2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethylsulfinyl)benzene

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Chemical Property of 1-chloro-4-(2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethylsulfinyl)benzene

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Technology Process of 1-chloro-4-(2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethylsulfinyl)benzene

There total 1 articles about 1-chloro-4-(2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethylsulfinyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 63383-26-6
1-chloro-4-(vinylsulfinyl)benzene

: 2216-51-5
(-)-menthol

: 1262638-54-9
1-chloro-4-(2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethylsulfinyl)benzene

: 1262638-55-0
1-chloro-4-(2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethylsulfinyl)benzene

Guidance literature:: (-)-menthol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

1-chloro-4-(vinylsulfinyl)benzene; With potassium hydride; In tetrahydrofuran; mineral oil; for 4h; Inert atmosphere; Resolution of racemate;
DOI:10.1021/ol102798f

Reference yield: 66.0%

: 1262638-55-0
1-chloro-4-(2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethylsulfinyl)benzene

: 217434-85-0
(+)-1-chloro-4-(vinylsulfinyl)benzene

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.0125h; Inert atmosphere;
DOI:10.1021/ol102798f

Reference yield:

: 1262638-55-0
1-chloro-4-(2-((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)ethylsulfinyl)benzene

: ((E)-3-((2S,3S,5S)-3-(4-chlorophenylsulfonyl)-2,5-dimethyl-5-vinyltetrahydrofuran-2-yl)allyl)trimethylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.01 h / -78 °C / Inert atmosphere

2.1: 2,6-di-tert-butyl-pyridine; t-butyldimethylsiyl triflate / acetonitrile / -30 °C / Inert atmosphere

2.2: 24 h / -30 °C / Inert atmosphere

3.1: potassium peroxomonosulfate; triethylamine / methanol; acetonitrile / 6 h / Inert atmosphere

4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / 1,2-dichloro-ethane / 4 h / 25 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; 2,6-di-tert-butyl-pyridine; potassium peroxomonosulfate; t-butyldimethylsiyl triflate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 1,2-dichloro-ethane; acetonitrile; 2.2: Diels-Alder reaction;
DOI:10.1021/ol102798f