(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride

Base Information

• Chemical Name: (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride
• CAS No.: 100165-54-6
• Molecular Formula: C₁₃H₁₉NO₅*ClH
• Molecular Weight: 305.759
• Mol file: 100165-54-6.mol

Synonyms:(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride

Chemical Property of (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride

There total 5 articles about (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl trans-4-<<(tert-butoxycarbonyl)amino>methyl>cyclohexanecarboxylate (100165-57-9) → (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride (100165-54-6)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 - 20 ℃; for 2.5h;

DOI:10.1021/jm00154a004

Reference yield:

4,5-Dimethyl-1,3-dioxole-2-one (37830-90-3) → (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride (100165-54-6)

Guidance literature:

Multi-step reaction with 3 steps

1: N-bromosuccinimide, α,α-azobis(isobutyronitrile) / CCl4

2: 41 percent / K₂CO₃, (C₄H₉)4NBr (QBr) / trichloroethene / 20 h / 60 °C

3: 70 percent / HCl(g) / ethyl acetate / 2.5 h / 0 - 20 °C

With hydrogenchloride; N-Bromosuccinimide; azobisisobutyronitrile; tetrabutylammomium bromide; potassium carbonate; In tetrachloromethane; Trichloroethylene; ethyl acetate;

DOI:10.1021/jm00154a004

Reference yield:

trans-4-aminomethyl-cyclohexyl-carboxylic acid (1197-18-8) → (5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl trans-4-(aminomethyl)cyclohexanecarboxylate hydrochloride (100165-54-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / NaOH / H₂O; 2-methyl-propan-2-ol / 18 h / Ambient temperature

2: 41 percent / K₂CO₃, (C₄H₉)4NBr (QBr) / trichloroethene / 20 h / 60 °C

3: 70 percent / HCl(g) / ethyl acetate / 2.5 h / 0 - 20 °C

With hydrogenchloride; sodium hydroxide; tetrabutylammomium bromide; potassium carbonate; In Trichloroethylene; water; ethyl acetate; tert-butyl alcohol;

DOI:10.1021/jm00154a004

upstream raw materials:

(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl trans-4-<<(tert-butoxycarbonyl)amino>methyl>cyclohexanecarboxylate

4,5-Dimethyl-1,3-dioxole-2-one

trans-4-aminomethyl-cyclohexyl-carboxylic acid

trans 4-(tert-butyloxycarbonylamino)methylcyclohexanecarboxylic acid

Refernces