(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

Base Information

Chemical Name:(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate
CAS No.:1402884-06-3
Molecular Formula:C₁₆H₁₆BrN₃O₃
Molecular Weight:378.225
Hs Code.:

Synonyms:(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

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Chemical Property of (1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

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Technology Process of (1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

There total 7 articles about (1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071-46-1
hydrogen ethyl malonate

: 1402883-85-5
(1R,2S)-1-(3-bromophenyl)-2-(3-ethoxy-3-oxopropanoyl)cyclopropanecarboxylic acid

: 593-85-1,90332-86-8,3425-08-9
diguanidine carbonate

: 74-88-4
methyl iodide

: 1402884-06-3
(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

Guidance literature:: hydrogen ethyl malonate; (1R,2S)-1-(3-bromophenyl)-2-(3-ethoxy-3-oxopropanoyl)cyclopropanecarboxylic acid; With sodium ethanolate; In ethanol; for 0.166667h;

diguanidine carbonate; In ethanol; at 95 ℃; for 14h;

methyl iodide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 21h;

Reference yield:

: C₁₅H₁₃BrN₃O₃^(1-)*Na⁽¹⁺⁾

: 74-88-4
methyl iodide

: 1402884-06-3
(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm3011405

Reference yield:

: 1402883-77-5
(1R,5S)-1-(3-bromophenyl)-3-oxabicyclo[3.1.0]hexan-2-one

: 1402884-06-3
(1R,2S)-methyl 2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)-1-(3-bromophenyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 20 °C

2.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 20 °C

3.1: 1,1'-carbonyldiimidazole / acetonitrile / 20 °C

3.2: 20 - 80 °C

4.1: sodium ethanolate / ethanol / 95 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With ruthenium trichloride; sodium periodate; sodium ethanolate; potassium carbonate; 1,1'-carbonyldiimidazole; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3011405