(8S,6R)-9-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-6-hydroxy-8-[(4-methoxyphenyl)methoxy]non-1-en-4-one

Base Information

Chemical Name:(8S,6R)-9-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-6-hydroxy-8-[(4-methoxyphenyl)methoxy]non-1-en-4-one
CAS No.:862465-66-5
Molecular Formula:C₂₆H₄₄O₅Si
Molecular Weight:464.718
Hs Code.:

Synonyms:(8S,6R)-9-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-6-hydroxy-8-[(4-methoxyphenyl)methoxy]non-1-en-4-one

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Chemical Property of (8S,6R)-9-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-6-hydroxy-8-[(4-methoxyphenyl)methoxy]non-1-en-4-one

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Technology Process of (8S,6R)-9-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-6-hydroxy-8-[(4-methoxyphenyl)methoxy]non-1-en-4-one

There total 7 articles about (8S,6R)-9-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-6-hydroxy-8-[(4-methoxyphenyl)methoxy]non-1-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 862465-65-4
(5S,3R)-6-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-3-hydroxy-N-methoxy-5-[(4-methoxyphenyl)methoxy]-N-methylhexanamide

: 1730-25-2
allylmagnesium bromide

: 862465-66-5
(8S,6R)-9-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-6-hydroxy-8-[(4-methoxyphenyl)methoxy]non-1-en-4-one

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 2h;
DOI:10.1021/ol051225n

Reference yield:

: 862465-63-2
tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate

: 862465-66-5
(8S,6R)-9-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-6-hydroxy-8-[(4-methoxyphenyl)methoxy]non-1-en-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / Raney Nickel; H₂ / ethanol / 3 h / 20 °C / 760 Torr

2: 90 percent / imidazole / CH₂Cl₂ / 16 h / 20 °C

3: 87 percent / isopropylmagnesium chloride / tetrahydrofuran / -30 - 0 °C

4: 93 percent / MgBr₂*Et₂O; n-tributyltin chloride / CH₂Cl₂ / 5 h / 20 °C

5: 89 percent / tetrahydrofuran / 2 h / 0 °C

With 1H-imidazole; tributyltin chloride; hydrogen; isopropylmagnesium chloride; nickel; magnesium bromide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol051225n

Reference yield:

: 862465-64-3
2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide

: 862465-66-5
(8S,6R)-9-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-6-hydroxy-8-[(4-methoxyphenyl)methoxy]non-1-en-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / MgBr₂*Et₂O; n-tributyltin chloride / CH₂Cl₂ / 5 h / 20 °C

2: 89 percent / tetrahydrofuran / 2 h / 0 °C

With tributyltin chloride; magnesium bromide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol051225n