tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate

Base Information

Chemical Name:tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate
CAS No.:862465-63-2
Molecular Formula:C₂₅H₃₂O₆
Molecular Weight:428.525
Hs Code.:

Synonyms:tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate

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Chemical Property of tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate

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Technology Process of tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate

There total 1 articles about tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 153716-95-1
(3R,5S)-6-benzyloxy-3,5-dihydroxy-hexanoic acid tert-butyl ester

: 862465-63-2
tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate

Guidance literature:: With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃;
DOI:10.1021/ol051225n

Reference yield: 89.0%

: 862465-63-2
tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate

: 625124-76-7
tert-butyl 2-[(6S,4R)-6-(hydroxymethyl)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]acetate

Guidance literature:: With hydrogen; nickel; In ethanol; at 20 ℃; for 3h; under 760 Torr;
DOI:10.1021/ol051225n

Reference yield:

: 862465-63-2
tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate

: 862465-69-8
4-(6-{(2S)-3-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-2-[(4-methoxyphenyl)methoxy]propyl}(4S,6R)-2,2-dimethyl(1,3-dioxan-4-yl))(2S,3R)-3-hydroxy-N-methoxy-2-methyl-N-methylbutanamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: 89 percent / Raney Nickel; H₂ / ethanol / 3 h / 20 °C / 760 Torr

2.1: 90 percent / imidazole / CH₂Cl₂ / 16 h / 20 °C

3.1: 87 percent / isopropylmagnesium chloride / tetrahydrofuran / -30 - 0 °C

4.1: 93 percent / MgBr₂*Et₂O; n-tributyltin chloride / CH₂Cl₂ / 5 h / 20 °C

5.1: 89 percent / tetrahydrofuran / 2 h / 0 °C

6.1: EtBOMe; NaBH₄ / tetrahydrofuran; methanol / 9 h / -78 °C

6.2: H₂O₂ / methanol; tetrahydrofuran; H₂O / -78 - 20 °C

7.1: 3.80 g / PPTs / CH₂Cl₂ / 1 h / 20 °C

8.1: 86 percent / pyridine; O₃; Sudan III / Ph₃P / CH₂Cl₂; methanol / -78 - 20 °C

9.1: n-Bu₂BOTf; Et₃N / CH₂Cl₂ / 1.5 h / -78 - 0 °C

9.2: 93 percent / CH₂Cl₂ / 2 h / -78 - 0 °C

10.1: 73 percent / AlMe₃ / tetrahydrofuran / 10 h / -10 - 0 °C

With pyridine; 1H-imidazole; sodium tetrahydroborate; oil scarlet; di-n-butylboryl trifluoromethanesulfonate; tributyltin chloride; hydrogen; trimethylaluminum; isopropylmagnesium chloride; pyridinium p-toluenesulfonate; nickel; ozone; triethylamine; magnesium bromide; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/ol051225n