2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide

Base Information

Chemical Name:2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide
CAS No.:862465-64-3
Molecular Formula:C₂₅H₄₃NO₆Si
Molecular Weight:481.705
Hs Code.:

Synonyms:2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide

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Chemical Property of 2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide

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Technology Process of 2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide

There total 5 articles about 2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 862465-84-7
tert-butyl 2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)-1,3-dioxan-4-yl)acetate

: 862465-64-3
2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide

Guidance literature:: With isopropylmagnesium chloride; In tetrahydrofuran; at -30 - 0 ℃;
DOI:10.1021/ol051225n

Reference yield:

: 862465-63-2
tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate

: 862465-64-3
2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / Raney Nickel; H₂ / ethanol / 3 h / 20 °C / 760 Torr

2: 90 percent / imidazole / CH₂Cl₂ / 16 h / 20 °C

3: 87 percent / isopropylmagnesium chloride / tetrahydrofuran / -30 - 0 °C

With 1H-imidazole; hydrogen; isopropylmagnesium chloride; nickel; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol051225n

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 862465-64-3
2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / PPTs / CH₂Cl₂ / 20 °C

2: 89 percent / Raney Nickel; H₂ / ethanol / 3 h / 20 °C / 760 Torr

3: 90 percent / imidazole / CH₂Cl₂ / 16 h / 20 °C

4: 87 percent / isopropylmagnesium chloride / tetrahydrofuran / -30 - 0 °C

With 1H-imidazole; hydrogen; isopropylmagnesium chloride; pyridinium p-toluenesulfonate; nickel; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol051225n