(5S,3R)-6-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-3-hydroxy-N-methoxy-5-[(4-methoxyphenyl)methoxy]-N-methylhexanamide

Base Information

Chemical Name:(5S,3R)-6-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-3-hydroxy-N-methoxy-5-[(4-methoxyphenyl)methoxy]-N-methylhexanamide
CAS No.:862465-65-4
Molecular Formula:C₂₅H₄₅NO₆Si
Molecular Weight:483.721
Hs Code.:

Synonyms:(5S,3R)-6-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-3-hydroxy-N-methoxy-5-[(4-methoxyphenyl)methoxy]-N-methylhexanamide

Suppliers and Price of (5S,3R)-6-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-3-hydroxy-N-methoxy-5-[(4-methoxyphenyl)methoxy]-N-methylhexanamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S,3R)-6-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-3-hydroxy-N-methoxy-5-[(4-methoxyphenyl)methoxy]-N-methylhexanamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5S,3R)-6-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-3-hydroxy-N-methoxy-5-[(4-methoxyphenyl)methoxy]-N-methylhexanamide

There total 6 articles about (5S,3R)-6-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-3-hydroxy-N-methoxy-5-[(4-methoxyphenyl)methoxy]-N-methylhexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 862465-64-3
2-((6S,4R)-6-{[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]methyl}-2-(4-methoxyphenyl)(1,3-dioxan-4-yl))-N-methoxy-N-methylacetamide

: 862465-65-4
(5S,3R)-6-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-3-hydroxy-N-methoxy-5-[(4-methoxyphenyl)methoxy]-N-methylhexanamide

Guidance literature:: With tributyltin chloride; magnesium bromide; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/ol051225n

Reference yield:

: 862465-63-2
tert-butyl 2-{(6S,4R)-2-(4-methoxyphenyl)-6-[(phenylmethoxy)methyl]-1,3-dioxan-4-yl}acetate

: 862465-65-4
(5S,3R)-6-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-3-hydroxy-N-methoxy-5-[(4-methoxyphenyl)methoxy]-N-methylhexanamide

Guidance literature:: Multi-step reaction with 4 steps

1: 89 percent / Raney Nickel; H₂ / ethanol / 3 h / 20 °C / 760 Torr

2: 90 percent / imidazole / CH₂Cl₂ / 16 h / 20 °C

3: 87 percent / isopropylmagnesium chloride / tetrahydrofuran / -30 - 0 °C

4: 93 percent / MgBr₂*Et₂O; n-tributyltin chloride / CH₂Cl₂ / 5 h / 20 °C

With 1H-imidazole; tributyltin chloride; hydrogen; isopropylmagnesium chloride; nickel; magnesium bromide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol051225n

Reference yield:

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 862465-65-4
(5S,3R)-6-[1,1-bis(1-methylethyl)-2-methyl-1-silapropoxy]-3-hydroxy-N-methoxy-5-[(4-methoxyphenyl)methoxy]-N-methylhexanamide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / PPTs / CH₂Cl₂ / 20 °C

2: 89 percent / Raney Nickel; H₂ / ethanol / 3 h / 20 °C / 760 Torr

3: 90 percent / imidazole / CH₂Cl₂ / 16 h / 20 °C

4: 87 percent / isopropylmagnesium chloride / tetrahydrofuran / -30 - 0 °C

5: 93 percent / MgBr₂*Et₂O; n-tributyltin chloride / CH₂Cl₂ / 5 h / 20 °C

With 1H-imidazole; tributyltin chloride; hydrogen; isopropylmagnesium chloride; pyridinium p-toluenesulfonate; nickel; magnesium bromide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/ol051225n