prop-2-yn-1-yl (S)-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Base Information

Chemical Name:prop-2-yn-1-yl (S)-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate
CAS No.:1579223-95-2
Molecular Formula:C₁₅H₁₈N₂O₄
Molecular Weight:290.319
Hs Code.:

Synonyms:prop-2-yn-1-yl (S)-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of prop-2-yn-1-yl (S)-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

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Technology Process of prop-2-yn-1-yl (S)-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

There total 2 articles about prop-2-yn-1-yl (S)-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 439912-45-5
((prop-2-yn-1-yloxy)carbonyl)-L-phenylalanine

: 1579223-95-2
prop-2-yn-1-yl (S)-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Guidance literature:: ((prop-2-yn-1-yloxy)carbonyl)-L-phenylalanine; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 1h;

N,O-dimethylhydroxylamine*hydrochloride; With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ml500088x

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1579223-95-2
prop-2-yn-1-yl (S)-(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / 16 h / 20 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h / 0 °C

2.2: 16 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In dichloromethane; water;
DOI:10.1021/ml500088x