N-(2-(5-acetyl-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide

Base Information

Chemical Name:N-(2-(5-acetyl-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide
CAS No.:1382991-56-1
Molecular Formula:C₃₂H₃₇FN₂O₂Si
Molecular Weight:528.742
Hs Code.:

Synonyms:N-(2-(5-acetyl-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-(5-acetyl-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide

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Technology Process of N-(2-(5-acetyl-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide

There total 10 articles about N-(2-(5-acetyl-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1382991-52-7
4-(3-fluorobenzyl)-N-(4-(triethylsilyl)but-3-ynyl)benzamide

: 97776-06-2
4-acetyl-2-iodoaniline

: 1382991-56-1
N-(2-(5-acetyl-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide

Guidance literature:: With sodium carbonate; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 100 ℃; for 18h;

Reference yield:

: 99-92-3
p-aminobenzophenone

: 1382991-56-1
N-(2-(5-acetyl-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: iodine; silver sulfate / ethanol / 18 h / 20 °C

2: sodium carbonate; lithium chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 18 h / 100 °C

With iodine; sodium carbonate; silver sulfate; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 768-35-4
3-fluorophenylboronic acid

: 1382991-56-1
N-(2-(5-acetyl-2-(triethylsilyl)-1H-indol-3-yl)ethyl)-4-(3-fluorobenzyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 0.25 h / 130 °C / Microwave irradiation

2.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 60 °C

3.1: thionyl chloride / chloroform / 18 h / 80 °C

4.1: triphenylphosphine / methanol / 2 h / 60 °C

4.3: 72 h / 20 °C

5.1: sodium carbonate; lithium chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 18 h / 100 °C

With thionyl chloride; water; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; lithium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; water; N,N-dimethyl-formamide;