3-(4-trifluoromethylphenyl)-5-(2-dimethylaminopropyl-1-amino)pyrazolo[1,5-a]quinazoline hydrochloride

Base Information

Chemical Name:3-(4-trifluoromethylphenyl)-5-(2-dimethylaminopropyl-1-amino)pyrazolo[1,5-a]quinazoline hydrochloride
CAS No.:1456789-40-4
Molecular Formula:C₂₂H₂₂F₃N₅*ClH
Molecular Weight:449.906
Hs Code.:

Synonyms:3-(4-trifluoromethylphenyl)-5-(2-dimethylaminopropyl-1-amino)pyrazolo[1,5-a]quinazoline hydrochloride

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Chemical Property of 3-(4-trifluoromethylphenyl)-5-(2-dimethylaminopropyl-1-amino)pyrazolo[1,5-a]quinazoline hydrochloride

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Technology Process of 3-(4-trifluoromethylphenyl)-5-(2-dimethylaminopropyl-1-amino)pyrazolo[1,5-a]quinazoline hydrochloride

There total 3 articles about 3-(4-trifluoromethylphenyl)-5-(2-dimethylaminopropyl-1-amino)pyrazolo[1,5-a]quinazoline hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1456789-17-5
5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one

: 109-55-7
1-amino-3-(dimethylamino)propane

: 1456789-40-4
3-(4-trifluoromethylphenyl)-5-(2-dimethylaminopropyl-1-amino)pyrazolo[1,5-a]quinazoline hydrochloride

Guidance literature:: 5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one; 1-amino-3-(dimethylamino)propane; With aluminum oxide; at 80 ℃; for 0.0333333h; Microwave irradiation;

With ethanol hydrochloride; In ethanol;
DOI:10.1021/jm400932c

Reference yield:

: 1456789-14-2
3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one

: 1456789-40-4
3-(4-trifluoromethylphenyl)-5-(2-dimethylaminopropyl-1-amino)pyrazolo[1,5-a]quinazoline hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: P,P-dichlorophenylphosphine oxide / 4 h / 180 °C

2: aluminum oxide / 0.03 h / 80 °C / Microwave irradiation

With P,P-dichlorophenylphosphine oxide; aluminum oxide;
DOI:10.1021/jm400932c

Reference yield:

: 2338-75-2
4-(Trifluoromethyl)phenylacetonitrile

: 1456789-40-4
3-(4-trifluoromethylphenyl)-5-(2-dimethylaminopropyl-1-amino)pyrazolo[1,5-a]quinazoline hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum oxide / 0.12 h / 150 °C / Microwave irradiation

2: P,P-dichlorophenylphosphine oxide / 4 h / 180 °C

3: aluminum oxide / 0.03 h / 80 °C / Microwave irradiation

With P,P-dichlorophenylphosphine oxide; aluminum oxide;
DOI:10.1021/jm400932c