5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one

Base Information

Chemical Name:5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one
CAS No.:1456789-17-5
Molecular Formula:C₁₇H₉ClF₃N₃
Molecular Weight:347.727
Hs Code.:

Synonyms:5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one

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Chemical Property of 5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one

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Technology Process of 5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one

There total 2 articles about 5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1456789-14-2
3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one

: 1456789-17-5
5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one

Guidance literature:: With P,P-dichlorophenylphosphine oxide; at 180 ℃; for 4h;
DOI:10.1021/jm400932c

Reference yield:

: 2338-75-2
4-(Trifluoromethyl)phenylacetonitrile

: 1456789-17-5
5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum oxide / 0.12 h / 150 °C / Microwave irradiation

2: P,P-dichlorophenylphosphine oxide / 4 h / 180 °C

With P,P-dichlorophenylphosphine oxide; aluminum oxide;
DOI:10.1021/jm400932c

Reference yield: 77.0%

: 1456789-17-5
5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one

: 108-00-9
N,N-dimethylethylenediamine

: 1456789-38-0
3-(4-trifluoromethylphenyl)-5-(2-dimethylaminoethylamino)pyrazolo[1,5-a]quinazoline hydrochloride

Guidance literature:: 5-chloro-3-(4-trifluoromethylphenyl)pyrazolo[1,5-a]quinazolin-5(4H)-one; N,N-dimethylethylenediamine; With aluminum oxide; at 80 ℃; for 0.0333333h; Microwave irradiation;

With ethanol hydrochloride; In ethanol;
DOI:10.1021/jm400932c