(+/-)-ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-<(2'-trans-phenylcyclopropyl)amino>acrylate

Base Information

• Chemical Name: (+/-)-ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-<(2'-trans-phenylcyclopropyl)amino>acrylate
• CAS No.: 103477-53-8
• Molecular Formula: C₂₁H₁₈Cl₂FNO₃
• Molecular Weight: 422.283
• Mol file: 103477-53-8.mol

Synonyms:(+/-)-ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-<(2'-trans-phenylcyclopropyl)amino>acrylate

Chemical Property of (+/-)-ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-<(2'-trans-phenylcyclopropyl)amino>acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-<(2'-trans-phenylcyclopropyl)amino>acrylate

There total 4 articles about (+/-)-ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-<(2'-trans-phenylcyclopropyl)amino>acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1R,2S)-1-amino-2-phenylcyclopropane (95-62-5,155-09-9,3721-26-4,3721-28-6,13531-35-6,24873-95-8,69684-88-4,69684-89-5,54-97-7) + 3-(2,4-dichloro-5-fluorophenyl)-3-oxo-2-ethoxymethylenepropanoic acid ethyl ester (104600-41-1) → (-)-ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-<<(1'R,2'S)-2'-phenylcyclopropyl>amino>acrylate (103477-53-8,103531-39-1,103531-40-4)

Guidance literature:

In dichloromethane; for 0.5h; Yield given; Ambient temperature;

DOI:10.1021/jm00160a042

Reference yield:

ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate (86483-51-4) → (-)-ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-<<(1'R,2'S)-2'-phenylcyclopropyl>amino>acrylate (103477-53-8,103531-39-1,103531-40-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride / 2 h / 110 °C

2: CH₂Cl₂ / 0.5 h / Ambient temperature

With acetic anhydride; In dichloromethane;

DOI:10.1021/jm00160a042

Reference yield:

ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate (86483-51-4) → (+/-)-ethyl 2-(2,4-dichloro-5-fluorobenzoyl)-3-<(2'-trans-phenylcyclopropyl)amino>acrylate (103477-53-8)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride / 2 h / 110 °C

2: CH₂Cl₂ / 0.5 h / Ambient temperature

With acetic anhydride; In dichloromethane;

DOI:10.1021/jm00160a042

upstream raw materials:

(1R,2S)-1-amino-2-phenylcyclopropane

3-(2,4-dichloro-5-fluorophenyl)-3-oxo-2-ethoxymethylenepropanoic acid ethyl ester

trans-2-phenylcyclopropylamine

ethyl 2,4-dichloro-5-fluoro-benzoyl-acetate

Downstream raw materials:

(+/-)-7-<4-(ethoxycarbonyl)piperazino>-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid ethyl piperazinecarboxylate salt

(+/-)-6-fluoro-7-piperazino-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

(+/-)-7-chloro-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid

(+/-)-7-chloro-6-fluoro-1-(2'-trans-phenylcyclopropyl)-1,4-dihydro-3-ethoxycarbonyl-4-oxoquinoline