2-azidoethyl 2-bromo-2-methylpropanoate

Base Information

• Chemical Name: 2-azidoethyl 2-bromo-2-methylpropanoate
• CAS No.: 1120364-53-5
• Molecular Formula: C₆H₁₀BrN₃O₂
• Molecular Weight: 236.068
• Mol file: 1120364-53-5.mol

Synonyms:2-azidoethyl 2-bromo-2-methylpropanoate

Chemical Property of 2-azidoethyl 2-bromo-2-methylpropanoate

Chemical Property:

• Refractive Index: n20/D1.482
• Flash Point: >110℃
• Density: 1.437 g/mL at 25 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Azidoethyl 2-bromoisobutyrate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Bifunctional initiator with a bromoisobutyryl moiety for atom transfer radical polymerization (ATRP) and an azide moiety that can be used in Cu-mediated ligation ("click" chemistry) for biomaterials, carbon nanotubes and graphene sheets.

Technology Process of 2-azidoethyl 2-bromo-2-methylpropanoate

There total 2 articles about 2-azidoethyl 2-bromo-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-2-methylpropionic acid (2052-01-9) + 2-azidoethanol (1517-05-1) → 2-azidoethyl 2-bromo-2-methylpropanoate (1120364-53-5)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 25h;

Reference yield: 91.0%

2-bromoisobutyric acid bromide (20769-85-1) + 2-azidoethanol (1517-05-1) → 2-azidoethyl 2-bromo-2-methylpropanoate (1120364-53-5)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 19h; Inert atmosphere;

DOI:10.1039/c1jm11613d

Reference yield: 87.5%

2-azidoethyl 2-bromo-2-methylpropanoate (1120364-53-5) + C50H44BF2N5O2 → C62H64BBr2F2N11O6

Guidance literature:

With tris[2-(dimethylamino)ethyl]amine; copper(I) bromide; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Sealed tube;

DOI:10.1002/anie.202114273

upstream raw materials:

2-bromo-2-methylpropionic acid

2-azidoethanol

2-bromoisobutyric acid bromide