Magnolol

Base Information

Chemical Name:Magnolol
CAS No.:528-43-8
Molecular Formula:C18H18O2
Molecular Weight:266.34
Hs Code.:29072990
European Community (EC) Number:610-903-7
NSC Number:293099
UNII:001E35HGVF
DSSTox Substance ID:DTXSID0044076
Nikkaji Number:J277.749E
Wikipedia:Magnolol
Wikidata:Q6732002
Metabolomics Workbench ID:67872
ChEMBL ID:CHEMBL180920
Mol file:528-43-8.mol

Synonyms:5,5'-diallyl-2,2'-dihydroxybiphenyl;magnolol

Suppliers and Price of Magnolol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Magnolol
20mg
$ 263.00

TRC
Magnolol
50mg
$ 55.00

TCI Chemical
5,5'-Diallyl-2,2'-dihydroxybiphenyl >98.0%(GC)
200mg
$ 47.00

TCI Chemical
5,5'-Diallyl-2,2'-dihydroxybiphenyl >98.0%(GC)
1g
$ 138.00

Sigma-Aldrich
Magnolol ≥95% (HPLC), from plant
10mg
$ 145.00

Sigma-Aldrich
Magnolol phyproof? Reference Substance
20 mg
$ 173.00

Sigma-Aldrich
Magnolol European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Magnolol European Pharmacopoeia (EP) Reference Standard
y0001289
$ 190.00

Oakwood
5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol 95+%
5g
$ 33.00

Matrix Scientific
5,5'-Diallyl-[1,1'-biphenyl]-2,2'-diol 95+%
1g
$ 185.00

Total 205 raw suppliers

Chemical Property of Magnolol

Chemical Property:

Appearance/Colour:A bioactive compound found in the bark of the Houpu magnolia.
Vapor Pressure:5.25E-07mmHg at 25°C
Melting Point:99 - 101oC
Refractive Index:1.601
Boiling Point:401 °C at 760 mmHg
PKA:9.49±0.43(Predicted)
Flash Point:184.5 °C
PSA：40.46000
Density:1.107 g/cm³
LogP:4.22180
Storage Temp.:2-8°C
Solubility.:ethanol: soluble1mg/mL
XLogP3:5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:266.130679813
Heavy Atom Count:20
Complexity:293

Purity/Quality:

Assay99%, ^*data from raw suppliers

Magnolol ^*data from reagent suppliers

Safty Information:

Pictogram(s): N
Hazard Codes:N
Statements: 37/38-41-51/53
Safety Statements: 26-39-61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=CCC1=CC(=C(C=C1)O)C2=C(C=CC(=C2)CC=C)O
Description Magnolol is an organic compound belonging to lignan. It is a kind of bioactive compounds identified from the bark of the Magnolia officinalis or M. grandiflora. It has been supplemented to Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic disease. It can act on the GABA receptor in vitro as a strong allosteric modulator. It also has antifungal effect, anti- periodontal activity as well as many osteoblast-stimulating and osteoclast-inhibiting activities. It has also found that magnolol can also activate the cannabinoid (CB) receptors. Magnolol is a bioactive compound isolated from the bark of M. officinalis that has been used in Asian traditional medicine for the treatment of anxiety, sleep disorders, and allergic diseases. Magnolol can activate cannabinoid (CB) receptors, behaving as a partial agonist with selectivity for the peripheral CB2 subtype (EC50 = 3.28 μM; Ki = 1.44 μM) versus central CB1 (EC50 = 18.3 μM; Ki = 3.15 μM).

Technology Process of Magnolol

There total 24 articles about Magnolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5,5'-Diallyl-2,2'-bis(methoxymethoxy)biphenyl

: 528-43-8
Magnolol

Guidance literature:: With chloro-trimethyl-silane; In methanol; at 0 - 25 ℃; for 1h;

Reference yield: 88.0%

: C₃₄H₃₄O₄

: 528-43-8
Magnolol

Guidance literature:: With manganese; (1,2-dimethoxyethane)dichloronickel(II); 1,1,3,3-Tetramethyldisiloxane; potassium tert-butylate; 1,3-bis(cyclohexyl)imidazolium tetrafluoroborate; In toluene; at 70 ℃; for 5h;
DOI:10.1021/acscatal.1c03980

Reference yield: 83.0%

: 5,5'-diallyl-2,2'-bis (benzyloxy)-1,1'-biphenyl

: 528-43-8
Magnolol

Guidance literature:: With manganese; (1,2-dimethoxyethane)dichloronickel(II); 1,1,3,3-Tetramethyldisiloxane; potassium tert-butylate; 1,3-bis(cyclohexyl)imidazolium tetrafluoroborate; In toluene; at 70 ℃; for 5h;
DOI:10.1021/acscatal.1c03980